[HTML][HTML] Epithelial-mesenchymal transition in cancer: a historical overview

D Ribatti, R Tamma, T Annese - Translational oncology, 2020 - Elsevier
Abstract Epithelial-mesenchymal transitions (EMTs), the acquisition of mesenchymal
features from epithelial cells, occur during some biological processes and are classified into …

Molecular mechanisms of epithelial–mesenchymal transition

S Lamouille, J Xu, R Derynck - Nature reviews Molecular cell biology, 2014 - nature.com
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as
epithelial–mesenchymal transition (EMT), is integral in development, wound healing and …

[HTML][HTML] Epithelial-mesenchymal transitions in development and disease

JP Thiery, H Acloque, RYJ Huang, MA Nieto - cell, 2009 - cell.com
The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the
body plan and in the differentiation of multiple tissues and organs. EMT also contributes to …

Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

H Peinado, D Olmeda, A Cano - Nature reviews cancer, 2007 - nature.com
The molecular mechanisms that underlie tumour progression are still poorly understood, but
recently our knowledge of particular aspects of some of these processes has increased …

[HTML][HTML] Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells

C Kudo-Saito, H Shirako, T Takeuchi, Y Kawakami - Cancer cell, 2009 - cell.com
Epithelial-mesenchymal transition (EMT) is a key step toward cancer metastasis, and Snail
is a major transcription factor governing EMT. Here, we demonstrate that Snail-induced EMT …

Preparing the “soil”: the premetastatic niche

RN Kaplan, S Rafii, D Lyden - Cancer research, 2006 - AACR
Current focus on cancer metastasis has centered on the intrinsic factors regulating the cell
autonomous homing of the tumor cells to the metastatic site. Specific up-regulation of …

[HTML][HTML] Heterogeneity in circulating tumor cells: the relevance of the stem-cell subset

C Agnoletto, F Corrà, L Minotti, F Baldassari, F Crudele… - Cancers, 2019 - mdpi.com
The release of circulating tumor cells (CTCs) into vasculature is an early event in the
metastatic process. The analysis of CTCs in patients has recently received widespread …

[HTML][HTML] ERβ impedes prostate cancer EMT by destabilizing HIF-1α and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading

P Mak, I Leav, B Pursell, D Bae, X Yang, CA Taglienti… - Cancer cell, 2010 - cell.com
High Gleason grade prostate carcinomas are aggressive, poorly differentiated tumors that
exhibit diminished estrogen receptor β (ERβ) expression. We report that a key function of …

Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells

H Kajiyama, K Shibata, M Terauchi… - International …, 2007 - spandidos-publications.com
The aim of this study was to assess paclitaxel resistant-epithelial ovarian carcinoma (EOC)
cells for cellular morphology, motility, and molecular changes consistent with epithelial …

MicroRNAs and the hallmarks of cancer

T Dalmay, DR Edwards - Oncogene, 2006 - nature.com
It has become clear that particular microRNAs (miRNAs) function either as tumour
suppressors or oncogenes, whose loss or overexpression, respectively, has diagnostic and …