It is well-known that the functioning of the immune system gradually deteriorates with age,
and we are increasingly confronted with its consequences as the life expectancy of the …

Many of the pathways that underlie the diversification of naive T cells into effector and
memory subsets, and the maintenance of these populations, remain controversial. In recent …

Historically, the immune system was believed to develop along a linear axis of maturity from
fetal life to adulthood. Now, it is clear that distinct layers of immune cells are generated from …

A timely recovery of T-cell numbers following haematopoietic stem-cell transplantation
(HSCT) is essential for preventing complications, such as increased risk of infection and …

In acute immune responses to infection, memory T cells develop that can spawn recall
responses. This process has not been observable directly in vivo. Here we highlight the …

The dynamics of cell populations are frequently studied in vivo using pulse-chase DNA
labeling techniques. When combined with mathematical models, the kinetic of label uptake …

Quantifying the kinetics with which memory T cell populations are generated and maintained
is essential for identifying the determinants of the duration of immunity. The quality and …

Hematopoietic stem cells and multipotential progenitors emerge in multiple, overlapping
waves of fetal development. Some of these populations seed the bone marrow and sustain …

The establishment and maintenance of peripheral T cells is important to ensure appropriate
immunity. In mammals, T cells are produced in the thymus before seeding the periphery …

Diabetes mellitus is considered as an autoimmune inflammatory and age-related disease.
As an important immune organ, the thymus is involved in the immune response and …