Mitogen‐activated protein kinase (MAPK) signaling pathways organize a great constitution
network that regulates several physiological processes, like cell growth, differentiation, and …

The number of descriptions of emerging viruses has grown at an unprecedented rate since
the beginning of the 21 st century. Severe acute respiratory syndrome coronavirus 2 (SARS …

Natural compounds are proper tools for inhibiting cancer cell proliferation. Hence, the
search for these ligands of overexpressed receptors in breast cancer has been a competitive …

Upregulation of epidermal growth factor receptor (EGFR) and subsequent increases in
extracellular-regulated kinase (ERK) and Akt signaling are implicated in prostate cancer …

Graphene is the strongest material ever studied and can be an efficient substitute for silicon.
This six-volume handbook focuses on fabrication methods, nanostructure and atomic …

Highlights•Comprehensive review of EGFRTK inhibitors.•Helps in understanding the
structural and developmental aspects of small molecular EGFR TKIs.•Focuses on mutant …

A series of benzothiazole/isatin linked to 1, 2, 3-triazole moiety and terminal sulpha drugs 5a-
e and 6a-e were synthesized and evaluated for cytotoxic activity against a panel of cancer …

The development of monoclonal antibody treatments for successful tumor-targeted therapies
took several decades. However, the efficacy of antibody-based therapy is still confined and …

Crosstalk mechanisms have not been studied as thoroughly as individual signaling
pathways. We exploit experimental and computational approaches to reveal how a …

Glioblastoma multiforme (GBM) is a highly lethal brain tumor for which little treatment is
available. The epidermal growth factor receptor (EGFR) signaling pathway is thought to play …