Navigating the synthesis of quinoline hybrid molecules as promising anticancer agents
P Panda, S Chakroborty - ChemistrySelect, 2020 - Wiley Online Library
The emergence of drug resistance and low specificity with side effects are the significant
challenges in pharmaceutical sectors for control of cancer nowadays. Notwithstanding, this …
challenges in pharmaceutical sectors for control of cancer nowadays. Notwithstanding, this …
Regioselective Functionalization of Quinolines through CH Activation: A Comprehensive Review
A Corio, C Gravier-Pelletier, P Busca - Molecules, 2021 - mdpi.com
Quinoline is a versatile heterocycle that is part of numerous natural products and countless
drugs. During the last decades, this scaffold also became widely used as ligand in …
drugs. During the last decades, this scaffold also became widely used as ligand in …
Quinoline–imidazole/benzimidazole derivatives as dual-/multi-targeting hybrids inhibitors with anticancer and antimicrobial activity
Two new classes of hybrid quinoline–imidazole/benzimidazole derivatives (the hybrid QIBS
salts and QIBC cycloadducts) were designed and synthesized to evaluate their anticancer …
salts and QIBC cycloadducts) were designed and synthesized to evaluate their anticancer …
New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with …
The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed
in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs …
in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs …
Mn(III)‐Mediated Regioselective 6‐endo‐trig Radical Cyclization of o‐Vinylaryl Isocyanides to Access 2‐Functionalized Quinolines
Y Liu, SJ Li, XL Chen, LL Fan, XY Li… - Advanced Synthesis …, 2020 - Wiley Online Library
A Mn (III)‐mediated radical cyclization reaction of o‐vinylaryl isocyanides and arylboronic
acids or diphenylphosphine oxides to access various 2‐functionalized quinolines under mild …
acids or diphenylphosphine oxides to access various 2‐functionalized quinolines under mild …
Quinoline derivatives: promising antioxidants with neuroprotective potential
Quinoline has been proposed as a privileged molecular framework in medicinal chemistry.
Although by itself it has very few applications, its derivatives have diverse biological …
Although by itself it has very few applications, its derivatives have diverse biological …
Quinoline-based Schiff bases as possible antidiabetic agents: ligand-based pharmacophore modeling, 3D QSAR, docking, and molecular dynamics simulations study
SD Ranade, SG Alegaon, NA Khatib, S Gharge… - RSC medicinal …, 2024 - pubs.rsc.org
α-Glucosidase enzyme inhibition is a legitimate approach to combat type 2 diabetes mellitus
as it manages to control postprandial hyperglycemia. In this pursuit, a literature search …
as it manages to control postprandial hyperglycemia. In this pursuit, a literature search …
Friedlӓnder's synthesis of quinolines as a pivotal step in the development of bioactive heterocyclic derivatives in the current era of medicinal chemistry
S Rajendran, K Sivalingam… - Chemical Biology & …, 2022 - Wiley Online Library
In the current scenario of medicinal chemistry, quinoline plays a pivotal role in the design of
new heterocyclic compounds with several pharmacological properties, so the search for new …
new heterocyclic compounds with several pharmacological properties, so the search for new …
The contemporary synthetic recipes to access versatile quinoline heterocycles
BS Matada, NG Yernale - Synthetic Communications, 2021 - Taylor & Francis
The synthesis of quinoline (C9H7N) and its derivatives attracted the attention of various
research communities due to their prominent roles in medicinal chemistry, coordination …
research communities due to their prominent roles in medicinal chemistry, coordination …
Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …