Navigating the synthesis of quinoline hybrid molecules as promising anticancer agents

P Panda, S Chakroborty - ChemistrySelect, 2020 - Wiley Online Library
The emergence of drug resistance and low specificity with side effects are the significant
challenges in pharmaceutical sectors for control of cancer nowadays. Notwithstanding, this …

Regioselective Functionalization of Quinolines through CH Activation: A Comprehensive Review

A Corio, C Gravier-Pelletier, P Busca - Molecules, 2021 - mdpi.com
Quinoline is a versatile heterocycle that is part of numerous natural products and countless
drugs. During the last decades, this scaffold also became widely used as ligand in …

Quinoline–imidazole/benzimidazole derivatives as dual-/multi-targeting hybrids inhibitors with anticancer and antimicrobial activity

D Diaconu, V Antoci, V Mangalagiu… - Scientific Reports, 2022 - nature.com
Two new classes of hybrid quinoline–imidazole/benzimidazole derivatives (the hybrid QIBS
salts and QIBC cycloadducts) were designed and synthesized to evaluate their anticancer …

New quinoline-based triazole hybrid analogs as effective inhibitors of α-amylase and α-glucosidase: Preparation, in vitro evaluation, and molecular docking along with …

Y Khan, S Iqbal, M Shah, A Maalik, R Hussain… - Frontiers in …, 2022 - frontiersin.org
The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed
in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs …

Mn(III)‐Mediated Regioselective 6‐endo‐trig Radical Cyclization of o‐Vinylaryl Isocyanides to Access 2‐Functionalized Quinolines

Y Liu, SJ Li, XL Chen, LL Fan, XY Li… - Advanced Synthesis …, 2020 - Wiley Online Library
A Mn (III)‐mediated radical cyclization reaction of o‐vinylaryl isocyanides and arylboronic
acids or diphenylphosphine oxides to access various 2‐functionalized quinolines under mild …

Quinoline derivatives: promising antioxidants with neuroprotective potential

LF Hernández-Ayala, EG Guzmán-López, A Galano - Antioxidants, 2023 - mdpi.com
Quinoline has been proposed as a privileged molecular framework in medicinal chemistry.
Although by itself it has very few applications, its derivatives have diverse biological …

Quinoline-based Schiff bases as possible antidiabetic agents: ligand-based pharmacophore modeling, 3D QSAR, docking, and molecular dynamics simulations study

SD Ranade, SG Alegaon, NA Khatib, S Gharge… - RSC medicinal …, 2024 - pubs.rsc.org
α-Glucosidase enzyme inhibition is a legitimate approach to combat type 2 diabetes mellitus
as it manages to control postprandial hyperglycemia. In this pursuit, a literature search …

Friedlӓnder's synthesis of quinolines as a pivotal step in the development of bioactive heterocyclic derivatives in the current era of medicinal chemistry

S Rajendran, K Sivalingam… - Chemical Biology & …, 2022 - Wiley Online Library
In the current scenario of medicinal chemistry, quinoline plays a pivotal role in the design of
new heterocyclic compounds with several pharmacological properties, so the search for new …

The contemporary synthetic recipes to access versatile quinoline heterocycles

BS Matada, NG Yernale - Synthetic Communications, 2021 - Taylor & Francis
The synthesis of quinoline (C9H7N) and its derivatives attracted the attention of various
research communities due to their prominent roles in medicinal chemistry, coordination …

Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)

MG Abo Al-Hamd, HO Tawfik, O Abdullah… - Journal of Enzyme …, 2023 - Taylor & Francis
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …