Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …

ABSTRACT Objective: Type 1 diabetes (T1D) is characterized by autoimmune β-cell
destruction, but exocrine pancreas abnormalities may also play a role in the disease …

BACKGROUND Residual C-peptide is detected in many people for years following the
diagnosis of type 1 diabetes; however, the physiologic significance of low levels of …

The pancreatic islet is a highly vascularized endocrine micro-organ. The unique architecture
of rodent islets, a so-called core-mantle arrangement seen in two-dimensional images, led …

An increasing number of studies have demonstrated that disease states of the endocrine or
exocrine pancreas aggravate one another, which implies bidirectional blood flow between …

Context. Type 1 diabetes (T1D) is a heterogeneous disease affecting the islets and the
exocrine pancreas. How the topographical distribution of the involved tissue lesions …

The endocrine and exocrine pancreas have been studied separately by endocrinologists
and gastroenterologists as two organ systems. The pancreatic islet, consisting of 1–2 …

Histopathological heterogeneity in the human pancreas is well documented; however,
functional evidence at the tissue level is scarce. Herein, we investigate in situ glucose …

The purpose of this review is to examine the current scientific literature regarding the
interplay between the exocrine and endocrine pancreas, specifically the role of the exocrine …

Introduction Despite a reduced function and volume of the exocrine pancreas in type 1
diabetes, the acinar cells remain understudied in type 1 diabetes research. The hypothesis …