[HTML][HTML] Biothermodynamics of viruses from absolute zero (1950) to virothermodynamics (2022)

M Popovic - Vaccines, 2022 - mdpi.com
Biothermodynamics of viruses is among the youngest but most rapidly developing scientific
disciplines. During the COVID-19 pandemic, it closely followed the results published by …

[HTML][HTML] XBB. 1.5 Kraken cracked: Gibbs energies of binding and biosynthesis of the XBB. 1.5 variant of SARS-CoV-2

ME Popovic - Microbiological research, 2023 - Elsevier
Abstract The SARS-CoV-2 Hydra with many heads (variants) has been causing the COVID-
19 pandemic for 3 years. The appearance of every new head (SARS-CoV-2 variant) causes …

[HTML][HTML] Strain Wars 4-Darwinian evolution through Gibbs' glasses: Gibbs energies of binding and growth explain evolution of SARS-CoV-2 from Hu-1 to BA. 2

M Popovic - Virology, 2022 - Elsevier
All processes in nature are driven by negative Gibbs energy. Gibbs energy is used by
various viruses and their strains to hijack host cell metabolic machinery. The analysis was …

Beyond COVID-19: Do biothermodynamic properties allow predicting the future evolution of SARS-CoV-2 variants?

M Popovic - Microbial risk analysis, 2022 - Elsevier
During the COVID-19 pandemic, many statistical and epidemiological studies have been
published, trying to predict the future development of the SARS-CoV-2 pandemic. However …

Strain wars 3: Differences in infectivity and pathogenicity between Delta and Omicron strains of SARS-CoV-2 can be explained by thermodynamic and kinetic …

M Popovic - Microbial risk analysis, 2022 - Elsevier
In this paper, for the first time, empirical formulas have been reported of the Delta and
Omicron strains of SARS-CoV-2. The empirical formula of the Delta strain entire virion was …

Why doesn't Ebola virus cause pandemics like SARS-CoV-2?

M Popovic - Microbial risk analysis, 2022 - Elsevier
Ebola virus is among the most dangerous, contagious and deadly etiological causes of viral
diseases. However, Ebola virus has never extensively spread in human population and …

[HTML][HTML] Omicron BA. 2.75 subvariant of SARS-CoV-2 is expected to have the greatest infectivity compared with the competing BA. 2 and BA. 5, due to most negative …

M Popovic - BioTech, 2022 - mdpi.com
Omicron BA. 2.75 may become the next globally dominant strain of COVID-19 in 2022. The
BA. 2.75 sub-variant has acquired more mutations (9) in spike protein and other genes of …

[HTML][HTML] Omicron BA. 2.75 sublineage (centaurus) follows the expectations of the evolution theory: less negative gibbs energy of biosynthesis indicates decreased …

M Popovic - Microbiology Research, 2022 - mdpi.com
SARS-CoV-2 belongs to the group of RNA viruses with a pronounced tendency to mutate.
Omicron BA. 2.75 is a subvariant believed to be able to suppress the currently dominant BA …

Never ending story? Evolution of SARS-CoV-2 monitored through Gibbs energies of biosynthesis and antigen-receptor binding of Omicron BQ. 1, BQ. 1.1, XBB and …

M Popovic - Microbial risk analysis, 2023 - Elsevier
RNA viruses exhibit a great tendency to mutate. Mutations occur in the parts of the genome
that encode the spike glycoprotein and less often in the rest of the genome. This is why …

Strain Wars 5: Gibbs energies of binding of BA. 1 through BA. 4 variants of SARS-CoV-2

M Popovic - Microbial risk analysis, 2022 - Elsevier
This paper reports, for the first time, standard Gibbs energies of binding of the BA. 1, BA. 2,
BA. 3, BA. 2.13, BA. 2.12. 1 and BA. 4 Omicron variants of SARS-CoV-2, to the Human ACE2 …