Cyclin D1 is an important regulator of cell cycle progression and can function as a
transcriptionl co-regulator. The overexpression of cyclin D1 has been linked to the …

Virus infections and autoimmune disease have long been linked. These infections often
precede the occurrence of inflammation in the target organ. Several mechanisms often used …

Autoimmunity occurs when the immune system recognizes and attacks host tissue. In
addition to genetic factors, environmental triggers (in particular viruses, bacteria and other …

Curcumin bioconjugates, viz. di-O-tryptophanylphenylalanine curcumin (2), di-O-decanoyl
curcumin (3), di-O-pamitoyl curcumin (4), di-O-bis-(γ, γ) folyl curcumin (6), C4-ethyl-O-γ-folyl …

The cellular biological function of the ubiquitin–proteasome pathway as a major intracellular
protein degradation pathway, and as an important modulator for the regulation of many …

Numerous infectious agents may trigger autoimmunity or even result in autoimmune
diseases. Several mechanisms have been proposed for pathogen-triggered autoimmunity …

Curcumin (diferuloylmethane), a natural polyphenolic compound extracted from the spice
turmeric, has been reported to have anti-inflammatory, antioxidant, and antiproliferative …

Iron (Fe) plays an important role in proliferation, and Fe deficiency results in G1/S arrest.
Despite this, the precise role of Fe in cell-cycle control remains unclear. Cyclin D1 plays a …

PTEN, a tumor suppressor phosphatase that dephosphorylates both protein and lipid
substrates, is mutated in both heritable and sporadic breast cancer. Until recently, PTEN …

Iron (Fe) plays a critical role in proliferation, and Fe deficiency results in G1/S arrest and
apoptosis. However, the precise role of Fe in cell-cycle control remains unclear. We …