E2F transcription factors and their regulatory partners, the pocket proteins (PPs), have
emerged as essential regulators of stem cell fate control in a number of lineages. In …

Cells in vivo are exposed to a complex signaling environment. Biochemical signaling
modalities, such as secreted proteins, specific extracellular matrix domains and ion fluxes …

Gene expression is controlled by the precise activation and repression of transcription.
Repression is mediated by specialized transcription factors (TFs) that recruit co-repressors …

Retinoblastoma (pRb) is a multifunctional regulator, which was likely present in the last
common ancestor of all eukaryotes. The Arabidopsis pRb homolog RETINOBLASTOMA …

The retinoblastoma tumor suppressor (RB) and its related family members p107 and p130
regulate cell proliferation through the transcriptional repression of genes involved in cellular …

Insulin signaling plays key roles in development, growth and metabolism through dynamic
control of glucose uptake, global protein translation and transcriptional regulation. Altered …

Lateral root (LR) formation is an example of a plant post-embryonic organogenesis event.
LRs are issued from non-dividing cells entering consecutive steps of formative divisions …

Retinoblastoma tumor suppressor proteins regulate the key transition from G1 to S phase of
the cell cycle. The mammalian Rb family comprises Rb, p107, and p130, with overlapping …

RBf2 is a recently evolved retinoblastoma family member in Drosophila that differs from
RBf1, especially in the C-terminus. To investigate whether the unique features of RBf2 …

The COP9 signalosome protein complex has a central role in the regulation of development
of multicellular organisms. While the function of this complex in ubiquitin-mediated protein …