Exploring traditional and nontraditional roles for thrombomodulin

H Loghmani, EM Conway - Blood, The Journal of the American …, 2018 - ashpublications.org
Thrombomodulin (TM) is an integral component of a multimolecular system, localized
primarily to the vascular endothelium, that integrates crucial biological processes and …

Thrombomodulin as a physiological modulator of intravascular injury

K Watanabe-Kusunoki, D Nakazawa, A Ishizu… - Frontiers in …, 2020 - frontiersin.org
Thrombomodulin (TM), which is predominantly expressed on the endothelium, plays an
important role in maintaining vascular homeostasis by regulating the coagulation system …

Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis

CN D'Alessandro-Gabazza, T Yasuma… - Nature …, 2022 - nature.com
Idiopathic pulmonary fibrosis is an incurable disease of unknown etiology. Acute
exacerbation of idiopathic pulmonary fibrosis is associated with high mortality. Excessive …

A Staphylococcus pro-apoptotic peptide induces acute exacerbation of pulmonary fibrosis

CN D'Alessandro-Gabazza, T Kobayashi… - Nature …, 2020 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a chronic and fatal disease of unknown etiology;
however, apoptosis of lung alveolar epithelial cells plays a role in disease progression. This …

Human-Based Advanced in vitro Approaches to Investigate Lung Fibrosis and Pulmonary Effects of COVID-19

M Kiener, N Roldan, C Machahua, A Sengupta… - Frontiers in …, 2021 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic has caused considerable socio-
economic burden, which fueled the development of treatment strategies and vaccines at an …

A four-part guide to lung immunology: Invasion, inflammation, immunity, and intervention

I Gopallawa, R Dehinwal, V Bhatia, V Gujar… - Frontiers in …, 2023 - frontiersin.org
Lungs are important respiratory organs primarily involved in gas exchange. Lungs interact
directly with the environment and their primary function is affected by several inflammatory …

Understanding idiopathic pulmonary fibrosis-clinical features, molecular mechanism and therapies

GS Suri, G Kaur, CK Jha, M Tiwari - Experimental gerontology, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic lung fibrosing disease with high prevalence
that has a prognosis worse than many cancers. There has been a recent influx of new …

[HTML][HTML] Inhibition of a microbiota-derived peptide ameliorates established acute lung injury

VF D'Alessandro, CN D'Alessandro-Gabazza… - The American Journal of …, 2023 - Elsevier
Acute lung injury (ALI) is a clinical syndrome characterized by a diffuse lung inflammation
that commonly evolves into acute respiratory distress syndrome and respiratory failure. The …

[HTML][HTML] Thrombomodulin ameliorates transforming growth factor-β1–mediated chronic kidney disease via the G-protein coupled receptor 15/Akt signal pathway

A Takeshita, T Yasuma, K Nishihama… - Kidney International, 2020 - Elsevier
Kidney fibrosis is the common consequence of chronic kidney diseases that inexorably
progresses to end-stage kidney disease with organ failure treatable only with replacement …

Macrophage‐based delivery of anti‐fibrotic proteins alleviates bleomycin‐induced pulmonary fibrosis in mice

H Liu, C Yang, Y Gao, X Zhang, M Wang… - Bioengineering & …, 2023 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by chronic,
progressive, and fibrotic lung injury. Although remarkable progress has been made toward …