The increased incidence of bacterial resistance to available antibiotics represents a major
global health problem and highlights the need for novel anti-infective therapies …

Antibiotic resistance is one of the greatest challenges of our time. This global health problem
originated from a paucity of truly effective antibiotic classes and an increased incidence of …

The lung contains numerous specialized cell types with distinct roles in tissue function and
integrity. To clarify the origins and mechanisms generating cell heterogeneity, we created a …

Neuropeptides (NPs) are the most versatile neurotransmitters in the immune systems that
regulate various central anxious hormones. An efficient and effective bioinformatics tool for …

Abstract SATPdb (http://crdd. osdd. net/raghava/satpdb/) is a database of structurally
annotated therapeutic peptides, curated from 22 public domain peptide databases/datasets …

Large contact surfaces of protein–protein interactions (PPIs) remain to be an ongoing issue
in the discovery and design of small molecule modulators. Peptides are intrinsically capable …

Neuropeptides play a variety of roles in many physiological processes and serve as
potential therapeutic targets for the treatment of some nervous-system disorders. In recent …

The field of proteomics is undergoing rapid development in a number of different areas
including improvements in mass spectrometric platforms, peptide identification algorithms …

Synaptic dysfunction and loss occur in Alzheimer's disease (AD) brains, which results in
cognitive deficits and brain neurodegeneration. Neuropeptides comprise the major group of …

Pulmonary neuroendocrine cells (PNECs) are sensory epithelial cells that transmit airway
status to the brain via sensory neurons and locally via calcitonin gene-related peptide …