DNA hypomethylation was the initial epigenetic abnormality recognized in human tumors.
However, for several decades after its independent discovery by two laboratories in 1983, it …

The process of DNA CpG methylation has been extensively investigated for over 50 years
and revealed associations between changing methylation status of CpG islands and gene …

Abstract Background Prostate cancer (PCa) has the highest incidence rates of cancers in
men in western countries. Unlike several other types of cancer, PCa has few genetic drivers …

Growing evidence suggests epigenetic alteration is involved during the development and
progression of prostate cancer. Previously, we found Nrf2, a key regulator of cellular …

Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) is a transcription factor which regulates
the expression of many cytoprotective genes. In the present study, we found that the …

BACKGROUND The clinical success of the nucleoside analogs 5‐aza‐cytidine (5‐azaC)
and 5‐aza‐2′ deoxycytidine (5‐aza‐dC) as DNA methyltransferase (DNMT) inhibitors has …

Epigenetic silencing of gluthathione‐S‐transferase pi (GSTP1) is recognized as being a
molecular hallmark of human prostate cancer. We investigated the effects of green tea …

DNA methylation plays an important role in regulating normal development and
carcinogenesis. Current understanding of the biological roles of DNA methylation is limited …

Human prostate cancer cells carry a myriad of genome defects, including both genetic and
epigenetic alterations. These changes, which can be maintained through mitosis, generate …

Background: Several human cancers have been found to contain cancer stem-like cells
(CSCs) having cancer-initiating ability. However, only a few reports have shown the …