Megakaryocytes are hematopoietic cells, which are responsible for the production of blood
platelets. The traditional view of megakaryopoiesis describes the cellular journey from …

Highlights•MK endomitosis is associated with both a defect in cytokinesis and
karyokinesis.•A myosin II accumulation defect at the furrow induces the cytokinesis …

Abstract Polo-like kinase 1 (Plk1) is overexpressed in a wide spectrum of human tumors,
being frequently considered as an oncogene and an attractive cancer target. However, its …

Considering the important side effects of conventional microtubule targeting agents, more
and more research focuses on regulatory proteins for the development of mitosis‐specific …

Liver dysfunction is an outstanding dose-limiting toxicity of gefitinib, an EGFR (epidermal
growth factor receptor)-tyrosine kinase inhibitor (TKI), in the treatment of EGFR mutation …

Abstract Trastuzumab-refractory, HER2 (human epidermal growth factor receptor 2)-positive
breast cancer is commonly treated with trastuzumab emtansine (T-DM1), an antibody–drug …

Abstract Polo-like kinase 1 (PLK1), an essential regulator of cell division, is currently
undergoing clinical evaluation as a target for cancer therapy. We report an unexpected …

Mammal megakaryocytes (MK) undergo polyploidization during their differentiation. This
process leads to a marked increase in the MK size and of their cytoplasm. Contrary to …

Normal hematopoiesis can be disrupted by the leukemic bone marrow microenvironment,
which leads to cytopenia-associated symptoms including anemia, hemorrhage and …

Platelets are blood cells derived from megakaryocytes that play a central role in regulating
haemostasis and vascular integrity. The microtubule cytoskeleton of megakaryocytes …