GPCRs: Emerging anti-cancer drug targets
AN Gutierrez, PH McDonald - Cellular signalling, 2018 - Elsevier
G protein-coupled receptors (GPCRs) constitute the largest and most diverse protein family
in the human genome with over 800 members identified to date. They play critical roles in …
in the human genome with over 800 members identified to date. They play critical roles in …
[HTML][HTML] Transactivation of epidermal growth factor receptor by G protein-coupled receptors: recent progress, challenges and future research
Z Wang - International journal of molecular sciences, 2016 - mdpi.com
Both G protein-coupled receptors (GPCRs) and receptor-tyrosine kinases (RTKs) regulate
large signaling networks, control multiple cell functions and are implicated in many diseases …
large signaling networks, control multiple cell functions and are implicated in many diseases …
[HTML][HTML] Structure, function, pharmacology, and therapeutic potential of the G protein, Gα/q, 11
G protein coupled receptors are one of the major classes of cell surface receptors and are
associated with a group of G proteins consisting of 3 subunits termed alpha, beta and …
associated with a group of G proteins consisting of 3 subunits termed alpha, beta and …
GPCRs and EGFR–Cross-talk of membrane receptors in cancer
M Köse - Bioorganic & medicinal chemistry letters, 2017 - Elsevier
G protein-coupled receptors (GPCRs) and receptor-tyrosine kinases (RTKs) are two
important classes of cell surface receptors proven to be highly tractable as drug targets. Both …
important classes of cell surface receptors proven to be highly tractable as drug targets. Both …
Lysophosphatidic acid and its receptors: pharmacology and therapeutic potential in atherosclerosis and vascular disease
Lysophosphatidic acid (LPA) is a collective name for a set of bioactive lipid species. Via six
widely distributed G protein-coupled receptors (GPCRs), LPA elicits a plethora of biological …
widely distributed G protein-coupled receptors (GPCRs), LPA elicits a plethora of biological …
Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-β signalling
Transforming growth factor (TGF)-β signalling pathways are intensively investigated
because of their diverse association with physiological and pathophysiological states. Smad …
because of their diverse association with physiological and pathophysiological states. Smad …
Gaq proteins: molecular pharmacology and therapeutic potential
Seven transmembrane G protein-coupled receptors (GPCRs) have gained much interest in
recent years as it is the largest class among cell surface receptors. G proteins lie in the heart …
recent years as it is the largest class among cell surface receptors. G proteins lie in the heart …
[HTML][HTML] Transforming growth factor-β receptors: versatile mechanisms of ligand activation
Transforming growth factor-β (TGF-β) signaling is initiated by activation of transmembrane
TGF-β receptors (TGFBR), which deploys Smad2/3 transcription factors to control cellular …
TGF-β receptors (TGFBR), which deploys Smad2/3 transcription factors to control cellular …
Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor
G protein-coupled receptor (GPCR) agonist endothelin-1 (ET-1) through transactivation of
the transforming growth factor (TGF) β receptor (TGFBR1) stimulates glycosaminoglycan …
the transforming growth factor (TGF) β receptor (TGFBR1) stimulates glycosaminoglycan …
[HTML][HTML] Smad2 linker region phosphorylation is an autonomous cell signalling pathway: Implications for multiple disease pathologies
This review will cover the signalling pathways leading to the phosphorylation of the Smad
linker region independent of Smad carboxy terminal phosphorylation. Characterising Smad …
linker region independent of Smad carboxy terminal phosphorylation. Characterising Smad …