Childhood maltreatment is the most important preventable risk factor for psychiatric
disorders. Maltreated individuals typically develop psychiatric disorders at an earlier age …

The odds ratio (OR) for gender differences in major depression is 1.95, averaged meta-
analytically over all ages and nations. The gender difference appears by age 12, OR= 2.37 …

Depression in youth is prevalent and disabling and tends to presage a chronic and recurrent
course of illness and impairment in adulthood. Clinical trial research in youth depression …

Objectives: Evidence suggests that childhood maltreatment may negatively affect not only
the lifetime risk of depression but also clinically relevant measures of depression, such as …

Few reliable predictors indicate which depressed individuals respond to antidepressants.
Several studies suggest that a history of early-life trauma predicts poorer response to …

Investigating the mechanisms through which psychotherapy brings about desired change
can inform efforts to improve therapies. We applied meta-analytic structural equation …

Background Childhood trauma is a common and potent risk factor for developing major
depressive disorder in adulthood, associated with earlier onset, more chronic or recurrent …

Epidemiological, clinical, and neurobiological studies of the last 30 years suggest that
traumatic attachments during the early years of life are associated to specific …

Background Childhood adversity is a risk factor for the development of depression and can
also affect clinical course. We investigated this specifically in treatment-resistant depression …

This study aimed to examine implementation feasibility and initial treatment outcomes of a
behavioral activation (BA) based treatment for adolescent depression, the Adolescent …