Predicting the effects of mutations in proteins is critical to many applications, from
understanding genetic disease to designing novel proteins to address our most pressing …

Protein mutagenesis is essential for unveiling the molecular mechanisms underlying protein
function in health, disease, and evolution. In the past decade, deep mutational scanning …

Current seasonal influenza vaccines, which mainly target hemagglutinin (HA), require
annual updates due to the continuous antigenic drift of the influenza virus. Developing an …

The influenza virus polymerase is central to influenza virus evolution. Adaptive mutations
within the polymerase are often a prerequisite for efficient spread of novel animal-derived …

Predicting the effects of mutations in proteins is critical to many applications, from
understanding genetic disease to designing novel proteins that can address our most …

Protein-protein interactions are crucial to many biological processes, and predicting the
effect of amino acid mutations on binding is important for protein engineering. While data …

Background Influenza virus (IV) is a leading cause of respiratory tract infections, eliciting
responses from key innate immune cells such as Macrophages (MQs), Neutrophils, and …

Insertions and deletions (InDels) are essential sources of novelty in protein evolution. In
RNA viruses, InDels cause dramatic phenotypic changes contributing to the emergence of …

Protein-protein bindings play a key role in a variety of fundamental biological processes,
and thus predicting the effects of amino acid mutations on protein-protein binding is crucial …

Influenza viruses present a significant threat to global health. The production of a universal
vaccine is considered essential due to the ineffectiveness of current seasonal influenza …