Karyopherin-mediated nucleocytoplasmic transport
Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …
Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities
Huntington disease (HD) is a neurodegenerative disease caused by CAG repeat expansion
in the huntingtin gene (HTT) and involves a complex web of pathogenic mechanisms …
in the huntingtin gene (HTT) and involves a complex web of pathogenic mechanisms …
Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma (BOSTON): a …
S Grosicki, M Simonova, I Spicka, L Pour, I Kriachok… - The Lancet, 2020 - thelancet.com
Background Selinexor combined with dexamethasone has shown activity in patients with
heavily pre-treated multiple myeloma. In a phase 1b/2 study, the combination of oral …
heavily pre-treated multiple myeloma. In a phase 1b/2 study, the combination of oral …
[HTML][HTML] An activity-guided map of electrophile-cysteine interactions in primary human T cells
Electrophilic compounds originating from nature or chemical synthesis have profound effects
on immune cells. These compounds are thought to act by cysteine modification to alter the …
on immune cells. These compounds are thought to act by cysteine modification to alter the …
Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation
P Tziortzouda, L Van Den Bosch, F Hirth - Nature Reviews …, 2021 - nature.com
Cytoplasmic aggregation of TAR DNA-binding protein 43 (TDP43; also known as TARDBP
or TDP-43) is a key pathological feature of several neurodegenerative diseases, including …
or TDP-43) is a key pathological feature of several neurodegenerative diseases, including …
[HTML][HTML] Stress granule assembly disrupts nucleocytoplasmic transport
Defects in nucleocytoplasmic transport have been identified as a key pathogenic event in
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mediated by a …
Mutant huntingtin disrupts the nuclear pore complex
Huntington's disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT)
gene. The mechanism (s) by which mutant HTT (mHTT) causes disease is unclear …
gene. The mechanism (s) by which mutant HTT (mHTT) causes disease is unclear …
The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease
A nucleotide repeat expansion (NRE) within the chromosome 9 open reading frame 72
(C9orf72) gene was the first of this type of mutation to be linked to multiple neurological …
(C9orf72) gene was the first of this type of mutation to be linked to multiple neurological …
Inhibitors of nuclear transport
DA Jans, AJ Martin, KM Wagstaff - Current opinion in cell biology, 2019 - Elsevier
Central to eukaryotic cell function, transport into and out of the nucleus is largely mediated
by members of the Importin (IMP) superfamily of transporters of α-and β-types. The first …
by members of the Importin (IMP) superfamily of transporters of α-and β-types. The first …
TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia
HC Archbold, KL Jackson, A Arora, K Weskamp… - Scientific reports, 2018 - nature.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive
neurodegenerative disorders marked in most cases by the nuclear exclusion and …
neurodegenerative disorders marked in most cases by the nuclear exclusion and …