Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory
cytokines, myokines, and osteokines, contribute substantially to the development of …

Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Adipose, skeletal, and hepatic muscle tissues are the main endocrine organs that produce
adipokines, myokines, and hepatokines. These biomarkers can be harmful or beneficial to …

Background Elevated lipids in umbilical cord blood affect fetal programming, leading to a
higher risk of developing cardiovascular disease in later life. However, the causes of …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …

Asprosin is a fasting-induced hormone that promotes glucose production in the liver and
stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an …

Adipokines secreted from white adipose tissue play a role in metabolic crosstalk and
homeostasis, whereas the brown adipose secretome is less explored. We performed high …

Severe inflammation in the islets is observed in obese patients with type 2 diabetes.
Inflammation in the islets is caused by obesity-induced serum free fatty acids. Asprosin is a …