Signaling pathways in obesity: mechanisms and therapeutic interventions
X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …
excessive fat accumulation in the body, obesity sharply increases the risk of several …
Cytokines and abnormal glucose and lipid metabolism
J Shi, J Fan, Q Su, Z Yang - Frontiers in endocrinology, 2019 - frontiersin.org
Clear evidence indicates that cytokines, for instance, adipokines, hepatokines, inflammatory
cytokines, myokines, and osteokines, contribute substantially to the development of …
cytokines, myokines, and osteokines, contribute substantially to the development of …
AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity
Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …
Adipokines, myokines, and hepatokines: crosstalk and metabolic repercussions
AR de Oliveira dos Santos… - International Journal of …, 2021 - mdpi.com
Adipose, skeletal, and hepatic muscle tissues are the main endocrine organs that produce
adipokines, myokines, and hepatokines. These biomarkers can be harmful or beneficial to …
adipokines, myokines, and hepatokines. These biomarkers can be harmful or beneficial to …
RETRACTED ARTICLE: Association of cord blood asprosin concentration with atherogenic lipid profile and anthropometric indices
Background Elevated lipids in umbilical cord blood affect fetal programming, leading to a
higher risk of developing cardiovascular disease in later life. However, the causes of …
higher risk of developing cardiovascular disease in later life. However, the causes of …
The melanocortin pathway and control of appetite-progress and therapeutic implications
G Baldini, KD Phelan - Journal of Endocrinology, 2019 - joe.bioscientifica.com
The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …
Adipose organ development and remodeling
S Cinti - Comprehensive Physiology, 2018 - iris.univpm.it
During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …
extension of obesity. Several observations converged on the idea that adipose tissues are …
OLFR734 mediates glucose metabolism as a receptor of asprosin
Asprosin is a fasting-induced hormone that promotes glucose production in the liver and
stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an …
stimulates appetite in the hypothalamus by activating the cAMP signaling pathway via an …
Proteomics-based comparative mapping of the secretomes of human brown and white adipocytes reveals EPDR1 as a novel batokine
AS Deshmukh, L Peijs, JL Beaudry, NZ Jespersen… - Cell Metabolism, 2019 - cell.com
Adipokines secreted from white adipose tissue play a role in metabolic crosstalk and
homeostasis, whereas the brown adipose secretome is less explored. We performed high …
homeostasis, whereas the brown adipose secretome is less explored. We performed high …
Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation
T Lee, S Yun, JH Jeong, TW Jung - Molecular and cellular endocrinology, 2019 - Elsevier
Severe inflammation in the islets is observed in obese patients with type 2 diabetes.
Inflammation in the islets is caused by obesity-induced serum free fatty acids. Asprosin is a …
Inflammation in the islets is caused by obesity-induced serum free fatty acids. Asprosin is a …