Interactions of melatonin with various signaling pathways: implications for cancer therapy
A Mihanfar, B Yousefi, B Azizzadeh… - Cancer Cell …, 2022 - Springer
Melatonin is a neuro-hormone with conserved roles in evolution. Initially synthetized as an
antioxidant molecule, it has gained prominence as a key molecule in the regulation of the …
antioxidant molecule, it has gained prominence as a key molecule in the regulation of the …
DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/Akt/mTOR signaling pathway
Y He, Y Dan, X Gao, L Huang… - American Journal of …, 2021 - journals.physiology.org
Diabetic retinopathy (DR) is one of the serious complications that occurs in diabetic patients
that frequently causes blindness. Long noncoding RNAs (lncRNAs) have been associated …
that frequently causes blindness. Long noncoding RNAs (lncRNAs) have been associated …
Mendelian disorders of PI metabolizing enzymes
More than twenty different genetic diseases have been described that are caused by
mutations in phosphoinositide metabolizing enzymes, mostly in phosphoinositide …
mutations in phosphoinositide metabolizing enzymes, mostly in phosphoinositide …
Cyanidin‐3‐glucoside attenuates the angiogenesis of breast cancer via inhibiting STAT3/VEGF pathway
X Ma, S Ning - Phytotherapy research, 2019 - Wiley Online Library
Angiogenesis plays a pivotal role in breast cancer progression. Cyanidin‐3‐glucoside
(C3G), one of the most widely distributed anthocyanins in edible fruits, shows antioxidative …
(C3G), one of the most widely distributed anthocyanins in edible fruits, shows antioxidative …
[HTML][HTML] Prodrug of epigallocatechin-3-gallate alleviates choroidal neovascularization via down-regulating HIF-1α/VEGF/VEGFR2 pathway and M1 type macrophage …
J Xu, Y Tu, Y Wang, X Xu, X Sun, L Xie, Q Zhao… - Biomedicine & …, 2020 - Elsevier
Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly and
is attributed to choroidal neovascularization (CNV), which is a feature of wet AMD. The …
is attributed to choroidal neovascularization (CNV), which is a feature of wet AMD. The …
Therapeutic potential of elema-1, 3, 7 (11), 8-tetraen-8, 12-lactam from Curcuma wenyujin on diabetic retinopathy via anti-inflammatory and anti-angiogenic pathways
Y Cai, H Tu, C Wu, T Liu, S Chen, L Shen… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance In traditional Chinese medicine, the causes of
diabetic retinopathy (DR) are blood stasis and heat. Curcuma wenyujin YH Chen & C. Ling …
diabetic retinopathy (DR) are blood stasis and heat. Curcuma wenyujin YH Chen & C. Ling …
[HTML][HTML] Angiogenesis effect of therapeutic ultrasound on HUVECs through activation of the PI3K-Akt-eNOS signal pathway
JJ Huang, YQ Shi, RL Li, A Hu, ZY Lu… - American journal of …, 2015 - ncbi.nlm.nih.gov
Therapeutic angiogenic effects of low-intensity ultrasound have been reported in endothelial
cells and animal models of hind limb ischemia. It has been shown that the proliferation …
cells and animal models of hind limb ischemia. It has been shown that the proliferation …
[HTML][HTML] High glucose-induced epithelial-mesenchymal transition contributes to the upregulation of fibrogenic factors in retinal pigment epithelial cells
D Che, T Zhou, Y Lan, J Xie… - International …, 2016 - spandidos-publications.com
It has been reported that epithelial-mesenchymal transition (EMT) mediates multiple
physiological and pathological processes. However, the occurrence and the pathogenic role …
physiological and pathological processes. However, the occurrence and the pathogenic role …
Substrate stiffening promotes VEGF-A functions via the PI3K/Akt/mTOR pathway
A Husain, A Khadka, A Ehrlicher… - Biochemical and …, 2022 - Elsevier
While it is now well-established that substrate stiffness regulates vascular endothelial growth
factor-A (VEGF-A) mediated signaling and functions, causal mechanisms remain poorly …
factor-A (VEGF-A) mediated signaling and functions, causal mechanisms remain poorly …
[HTML][HTML] System-wide vitreous proteome dissection reveals impaired sheddase activity in diabetic retinopathy
A Alli-Shaik, B Qiu, SL Lai, N Cheung, G Tan… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Diabetic retinopathy (DR) is a major complication of diabetes mellitus causing
significant vision loss. DR is a multifactorial disease involving changes in retinal …
significant vision loss. DR is a multifactorial disease involving changes in retinal …