Iron acquisition systems of gram-negative bacterial pathogens define TonB-dependent pathways to novel antibiotics

PE Klebba, SMC Newton, DA Six, A Kumar… - Chemical …, 2021 - ACS Publications
Iron is an indispensable metabolic cofactor in both pro-and eukaryotes, which engenders a
natural competition for the metal between bacterial pathogens and their human or animal …

Pseudomonas aeruginosa and its multiple strategies to access iron

IJ Schalk, Q Perraud - Environmental Microbiology, 2023 - Wiley Online Library
Pseudomonas aeruginosa is a ubiquitous bacterium found in many natural and man‐made
environments. It is also a pathogen for plants, animals, and humans. As for almost all living …

A review of chemical signaling pathways in the quorum sensing circuit of Pseudomonas aeruginosa

K Vadakkan, AK Ngangbam, K Sathishkumar… - International Journal of …, 2023 - Elsevier
Pseudomonas aeruginosa, an increasingly common competitive and biofilm organism in
healthcare infection with sophisticated, interlinked and hierarchic quorum systems (Las, Rhl …

Ferric iron reductases and their contribution to unicellular ferrous iron uptake

TJ Cain, AT Smith - Journal of inorganic biochemistry, 2021 - Elsevier
Iron is a necessary element for nearly all forms of life, and the ability to acquire this trace
nutrient has been identified as a key virulence factor for the establishment of infection by …

[HTML][HTML] Novel insights on pyoverdine: from biosynthesis to biotechnological application

F Dell'Anno, GA Vitale, C Buonocore, L Vitale… - International Journal of …, 2022 - mdpi.com
Pyoverdines (PVDs) are a class of siderophores produced mostly by members of the genus
Pseudomonas. Their primary function is to accumulate, mobilize, and transport iron …

Identification of novel heavy metal detoxification proteins in Solanum tuberosum: Insights to improve food security protection from metal ion stress

G He, W Tian, L Qin, L Meng, D Wu, Y Huang… - Science of The Total …, 2021 - Elsevier
With increasingly serious environmental pollution problems, research has focused on
identifying functional genes within plants that can help ensure food security and soil …

Emerging role of ferrous iron in bacterial growth and host–pathogen interaction: New tools for chemical (micro) biology and antibacterial therapy

RL Gonciarz, AR Renslo - Current opinion in chemical biology, 2021 - Elsevier
Chemical tools capable of detecting ferrous iron with oxidation-state specificity have only
recently become available. Coincident with this development in chemical biology has been …

Bacterial siderophores: diversity, uptake pathways and applications

IJ Schalk - Nature Reviews Microbiology, 2024 - nature.com
Iron is an essential nutrient for the growth, survival and virulence of almost all bacteria. To
access iron, many bacteria produce siderophores, molecules with a high affinity for iron …

Succinate accumulation contributes to oxidative stress and iron accumulation in pentylenetetrazol-induced epileptogenesis and kainic acid-induced seizure

Y Zhang, Y Cui, Y Cheng, W Zhu, M Zhang, S Li… - Neurochemistry …, 2021 - Elsevier
This study explored the role of succinate accumulation in the oxidative stress and iron
accumulation in both pentylenetetrazol (PTZ)-induced epileptogenesis and kainic acid (KA) …

Structural and thermodynamic insights into a novel Mg2+–citrate-binding protein from the ABC transporter superfamily

SK Mandal, SP Kanaujia - Acta Crystallographica Section D …, 2021 - journals.iucr.org
More than one third of proteins require metal ions to accomplish their functions, making them
obligatory for the growth and survival of microorganisms in varying environmental niches. In …