The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

For over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-
promoting factors and formins were the only molecules known to directly nucleate actin …

The cellular functions of the actin cytoskeleton require precise regulation of both the
initiation of actin polymerization and the organization of the resulting filaments. The actin …

This review summarizes what is known about the biochemical and biophysical mechanisms
that initiate the assembly of actin filaments in cells. Assembly and disassembly of these …

To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …

The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …

Arp2/3 complex nucleates branched actin filaments that provide pushing forces to drive
cellular processes such as lamellipodial protrusion and endocytosis. Arp2/3 complex is …

Recent advances in structural, biochemical, biophysical, and live cell imaging approaches
have furthered our understanding of the molecular mechanisms by which regulated …

Cells are active materials; they can change shape using internal energy to build contractile
networks of actin filaments and myosin motors. Contractility of the actomyosin cortex is tightly …

The Arp2/3 complex consists of seven evolutionarily conserved subunits (Arp2, Arp3 and
ARPC1–5) and plays an essential role in generating branched actin filament networks …