Correct development of the human placenta and its differentiated epithelial cells, syncytial
trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful …

In humans, cell fusion is restricted to only a few cell types under normal conditions. In the
placenta, cell fusion is a critical process for generating syncytiotrophoblast: the giant …

Short telomeres trigger age-related pathologies and shorter lifespans in mice and humans.
In the past, we generated mouse embryonic (ES) cells with longer telomeres than normal …

Remodeling of the uterine vasculature by invasive extravillous trophoblasts (EVTs) is a
critical aspect of human placentation. Insufficient EVT invasion can lead to severe obstetrical …

Background Therapeutic resistance to radiation and chemotherapy is one of the major
obstacles in cancer treatment. Although synthetic radiosensitizers are pragmatic solution to …

Proper development of the placenta is vital for pregnancy success. The placenta regulates
exchange of nutrients and gases between maternal and fetal blood and produces hormones …

Thyroid hormones (THs) regulate a number of metabolic processes during pregnancy. After
implantation, the placenta forms and enhances embryonic growth and development …

Tobacco smoking is an important public health issue recognized by the world health
organization as one of the most serious, preventable risk factors for developing a series of …

Recurrent spontaneous abortion (RSA) is a serious pregnancy complication with an
increasing clinical incidence. The various causes of recurrent abortion are complicated …

Preeclampsia is not fully understood; and few biomarkers, therapeutic targets, and
therapeutic agents for its management have been identified. Original investigative findings …