The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs)
were originally characterized as passive reservoirs of circulating IGFs, but they are now …

microRNAs (miRNAs) are a new class of non-protein-coding, endogenous, small RNAs.
They are important regulatory molecules in animals and plants. miRNA regulates gene …

Insulin‐like growth factors (IGFs) are essential for growth and survival that suppress
apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in …

Abstract microRNAs (miRNAs) are frequently dysregulated in human malignancies. It was
recently shown that miR-204-5p is downregulated in papillary thyroid carcinoma (PTC); …

Background MicroRNAs (miRNAs, miRs) are small non-coding RNAs that negatively
regulate gene expression at the post-transcriptional level. MicroRNAs are dysregulated in …

IGF-II stimulates both mitogenesis and myogenesis through its binding and activation of the
IGF-I receptor (IGF-IR). How this growth factor pathway promotes these two opposite cellular …

Ionizing radiation is an important treatment modality, but it is also a well-known genotoxic
agent capable of damaging cells and tissues. Therefore radiation treatment can cause …

Mesenchymal stem cells, or multipotent mesenchymal stromal cells (MSC), isolated from
various adult tissue sources have the capacities to self-renew and to differentiate into …

In the recent years, RNA interference (RNAi) has emerged as a major regulatory mechanism
in eukaryotic gene expression. The realization that changes in the levels of microRNAs are …

MicroRNAs (miRNAs) are a novel class of small noncoding RNAs that regulate gene
expression at the post-transcriptional level and play a critical role in many important …