O6-Methylguanine-DNA-methyltransferase (MGMT) is a unique protein, which both repairs
O6-alkylguanine lesions stoichiometrically without a multi-enzymatic pathway and self …

The majority of lung cancers are caused by long term exposure to the several classes of
carcinogens present in tobacco smoke. Although a significant fraction of lung cancers in …

Lung cancer is a leading cause of cancer mortality with an inter-individual difference in
susceptibility to the disease. The inheritance of low-efficiency genotypes involved in DNA …

Environmental tobacco smoke (ETS), or second-hand smoke, is a widespread contaminant
of indoor air in environments where smoking is not prohibited. It is a significant source of …

Abstract O 6-methylguanine-DNA methyltransferase (MGMT) is a repair enzyme that
removes promutagenic O 6-methylguanine adducts in DNA, to protect cells from acquisition …

Tobacco and alcohol consumption are the major risk factors for head and neck cancer, likely
due to DNA-damaging processes. Genetic variations in DNA repair genes may affect an …

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a
potent pulmonary carcinogen in laboratory animals. It is classified as a Group 1 human …

Global statistics estimate that approximately 25% of patients with lung cancer are never
smokers. We suggest that genes related to susceptibility to metabolic syndrome were …

Lung cancer in never smokers (LCINS) has lately been recognized as a unique disease
based on rapidly gained knowledge from genomic changes to treatment responses. The …

Abstract O 6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein which
protects the cellular genome and critical oncogenic genes from the mutagenic action of …