Long-range interactions between transcription regulatory elements play an important role in
gene activation, epigenetic silencing, and chromatin organization. Transcriptional activation …

Chromosomes are large polymer molecules composed of nucleotides. In some species,
such as humans, this polymer can sum up to meters long and still be properly folded within …

Chromatin has a complex spatial organization in the cell nucleus that serves vital functional
purposes. A variety of chromatin folding conformations has been detected by single-cell …

In this series of papers new results and a brief review of the current state of mean-field
theories of the condensed globular state and of the globule-to-coil transition in the-region for …

The recent experimental data on stages and kinetic intermediates in protein folding are
reviewed. It is emphasized that these data are consistent with the 'framework …

During an organism's ontogeny and in the adult, each B and T lymphocyte generates a
unique antigen receptor, thereby creating the organism's ability to respond to a vast number …

The complex three-dimensional (3D) structure of the genome plays critical roles in the
maintenance of genome stability, organization, and dynamics and in regulation of gene …

Using a coarse-grained model we perform a Monte Carlo simulation of the state behavior of
an individual semiflexible macromolecule. Chains consisting of N= 256 and 512 monomer …

The DNA‐passage activity of topoisomerase II accidentally produces DNA knots and
interlinks within and between chromatin fibers. Fortunately, these unwanted DNA …

Multiple studies suggest that chromatin looping might play a crucial role in organizing
eukaryotic genomes. To investigate the interplay between the conformation of interphase …