Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is characterised by the progressive loss of motor neurons in
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …
the brain and spinal cord. This neurodegenerative syndrome shares pathobiological …
Gene therapy for neurological disorders: progress and prospects
Adeno-associated viral (AAV) vectors are a rapidly emerging gene therapy platform for the
treatment of neurological diseases. In preclinical studies, transgenes encoding therapeutic …
treatment of neurological diseases. In preclinical studies, transgenes encoding therapeutic …
[HTML][HTML] Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial
RH Baloh, JP Johnson, P Avalos, P Allred… - Nature medicine, 2022 - nature.com
Amyotrophic lateral sclerosis (ALS) involves progressive motor neuron loss, leading to
paralysis and death typically within 3–5 years of diagnosis. Dysfunctional astrocytes may …
paralysis and death typically within 3–5 years of diagnosis. Dysfunctional astrocytes may …
Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies
DR Beers, SH Appel - The Lancet Neurology, 2019 - thelancet.com
Neuroinflammation is a common pathological feature of many neurodegenerative diseases,
including amyotrophic lateral sclerosis (ALS), and is characterised by activated CNS …
including amyotrophic lateral sclerosis (ALS), and is characterised by activated CNS …
[HTML][HTML] A first-in-human, phase I study of neural stem cell transplantation for chronic spinal cord injury
E Curtis, JR Martin, B Gabel, N Sidhu, TK Rzesiewicz… - Cell stem cell, 2018 - cell.com
We tested the feasibility and safety of human-spinal-cord-derived neural stem cell (NSI-566)
transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four …
transplantation for the treatment of chronic spinal cord injury (SCI). In this clinical trial, four …
Amyotrophic lateral sclerosis: an update for 2018
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting motor neurons
and other neuronal cells, leading to severe disability and eventually death from ventilatory …
and other neuronal cells, leading to severe disability and eventually death from ventilatory …
Amyotrophic lateral sclerosis
RH Brown, A Al-Chalabi - New England Journal of Medicine, 2017 - Mass Medical Soc
Amyotrophic Lateral Sclerosis | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
[HTML][HTML] Role of neuroinflammation in amyotrophic lateral sclerosis: cellular mechanisms and therapeutic implications
J Liu, F Wang - Frontiers in immunology, 2017 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from …
upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from …
Pharmacotherapy for amyotrophic lateral sclerosis: a review of approved and upcoming agents
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
involving loss of upper and lower motor neurons, with most cases ending in death within 3–5 …
involving loss of upper and lower motor neurons, with most cases ending in death within 3–5 …
[HTML][HTML] Therapies to restore consciousness in patients with severe brain injuries: a gap analysis and future directions
Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …
families, the search for new therapies has been a source of hope and frustration. Almost all …