Irritable bowel syndrome (IBS) is the most common functional bowel disorder worldwide and
is associated with visceral hypersensitivity, gut motility, immunomodulation, gut microbiota …

The gastrointestinal tract harbours the largest population of mast cells in the body; this highly
specialised leukocyte cell type is able to adapt its phenotype and function to the …

Mast cells are important components of the immune system, and they perform pro-
inflammatory as well as anti-inflammatory roles in the complex process of immune regulation …

IgE-dependent mast cell activation is a major effector mechanism underlying the pathology
associated with allergic disorders. The most dramatic of these IgE-associated disorders is …

Fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs)
are carbohydrates thought to contribute to the symptoms of IBS. A diet in high in FODMAPs …

Irritable bowel syndrome (IBS) is one of the most prevalent functional gastrointestinal
disorders, and accumulating evidence gained in both preclinical and clinical studies indicate …

ABSTRACT Obesity, insulin resistance (IR), and the gut microbiome intricately interplay in
Metabolic-associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic …

Abstract Background Mast cells (MCs) have been found to play a critical role during
development of inflammatory bowel disease (IBD) that characterized by dysregulation of …

Systemic inflammation mediated by Plasmodium parasites is central to malaria disease and
its complications. Plasmodium parasites reside in erythrocytes and can theoretically reach …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. The mechanisms involved in NAFLD onset are complicated and multifactorial …