The diagnosis and treatment of invasive breast cancer requires a collaborative effort among
multiple subspecialties. Diagnostic imaging workup and biopsy play a key role in …

Breast cancer is a heterogeneous disease that affects one anatomic site, yet is
phenotypically variable. 1, 2 The identification of different biological subtypes occurs …

The therapeutic options for patients with noninvasive or invasive breast cancer are complex
and varied. These NCCN Clinical Practice Guidelines for Breast Cancer include …

Importance The results of the American College of Surgeons Oncology Group Z0011
(ACOSOG Z0011) trial were first reported in 2005 with a median follow-up of 6.3 years …

Background Local cancer relapse risk after breast conservation surgery followed by
radiotherapy has fallen sharply in many countries, and is influenced by patient age and …

These NCCN Guidelines Insights highlight the important updates/changes to the surgical
axillary staging, radiation therapy, and systemic therapy recommendations for hormone …

Importance Prospective trials have demonstrated sentinel lymph node (SLN) false-negative
rates of less than 10% when 3 or more SLNs are retrieved in patients with clinically node …

The prognosis of patients with early stage breast cancer has greatly improved in the past
three decades. Following the first adjuvant endocrine therapy and chemotherapy trials …

Advances in molecular testing have ushered in the new era of precision medicine. The 2018
publication of the TAILORx trial helped refine the use of genetic expression assays …

Background Completion axillary lymph node dissection is overtreatment for patients with
sentinel lymph node (SLN) metastasis in whom the metastatic risk of residual non-SLN …