Prefrontal cortex development in health and disease: lessons from rodents and humans

M Chini, IL Hanganu-Opatz - Trends in neurosciences, 2021 - cell.com
The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …

Regeneration of spinal cord connectivity through stem cell transplantation and biomaterial scaffolds

H Katoh, K Yokota, MG Fehlings - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Significant progress has been made in the treatment of spinal cord injury (SCI). Advances in
post-trauma management and intensive rehabilitation have significantly improved the …

[HTML][HTML] Saturated reconstruction of a volume of neocortex

N Kasthuri, KJ Hayworth, DR Berger, RL Schalek… - Cell, 2015 - cell.com
We describe automated technologies to probe the structure of neural tissue at nanometer
resolution and use them to generate a saturated reconstruction of a sub-volume of mouse …

Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring

F Mirabella, G Desiato, S Mancinelli, G Fossati… - Immunity, 2021 - cell.com
Early prenatal inflammatory conditions are thought to be a risk factor for different
neurodevelopmental disorders. Maternal interleukin-6 (IL-6) elevation during pregnancy …

[HTML][HTML] Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders

KP Lesch, J Waider - Neuron, 2012 - cell.com
Serotonin (5-HT) shapes brain networks during development and modulates a wide
spectrum of essential neuronal functions ranging from perception and cognitive appraisal to …

The calcium channel subunit Alpha2delta2 suppresses axon regeneration in the adult CNS

A Tedeschi, S Dupraz, CJ Laskowski, J Xue, T Ulas… - Neuron, 2016 - cell.com
Injuries to the adult CNS often result in permanent disabilities because neurons lose the
ability to regenerate their axon during development. Here, whole transcriptome sequencing …

Specification of synaptic connectivity by cell surface interactions

J De Wit, A Ghosh - Nature Reviews Neuroscience, 2016 - nature.com
The molecular diversification of cell surface molecules has long been postulated to impart
specific surface identities on neuronal cell types. The existence of unique cell surface …

CircRNAs in the brain

M Hanan, H Soreq, S Kadener - RNA biology, 2017 - Taylor & Francis
Circular RNAs (circRNAs) are highly abundant and evolutionarily conserved non-coding
RNAs produced by circularization of specific exons. Since their re-discovery as potential …

The perineuronal net and the control of CNS plasticity

D Wang, J Fawcett - Cell and tissue research, 2012 - Springer
Perineuronal nets (PNNs) are reticular structures that surround the cell body of many
neurones, and extend along their dendrites. They are considered to be a specialized …

[HTML][HTML] FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development

ML O'Sullivan, J de Wit, JN Savas, D Comoletti… - Neuron, 2012 - cell.com
Latrophilins (LPHNs) are a small family of G protein-coupled receptors known to mediate the
massive synaptic exocytosis caused by the black widow spider venom α-latrotoxin, but their …