There is great potential for genome sequencing to enhance patient care through improved
diagnostic sensitivity and more precise therapeutic targeting. To maximize this potential …

Genome sequencing and analysis allow researchers to decode the functional information
hidden in DNA sequences as well as to study cell to cell variation within a cell population …

Abstract The Sequence Alignment/Map (SAM) format file is the text file used to record
alignment information. Alignment is the core of sequencing analysis, and downstream tasks …

Abstract Motivation High-Throughput Sequencing technologies produce huge amounts of
data in the form of short genomic reads, associated quality values and read identifiers …

We consider lossless compression based on statistical data modeling followed by prediction-
based encoding, where an accurate statistical model for the input data leads to substantial …

Recent advancements in sequencing technology have led to a drastic reduction in genome
sequencing costs. This development has generated an unprecedented amount of data that …

Recently, there has been growing interest in genome sequencing, driven by advances in
sequencing technology, in terms of both efficiency and affordability. These developments …

Motivation The affordability of DNA sequencing has led to the generation of unprecedented
volumes of raw sequencing data. These data must be stored, processed and transmitted …

The amount of data produced by modern sequencing instruments that needs to be stored is
huge. Therefore it is not surprising that a lot of work has been done in the field of specialized …

Abstract Motivation New Generation Sequencing (NGS) technologies for genome
sequencing produce large amounts of short genomic reads per experiment, which are highly …