Chemically modified platforms for better RNA therapeutics
RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …
landscape, offering unprecedented potential in disease prevention and treatment. However …
Nucleic acids in modern molecular therapies: A realm of opportunities for strategic drug design
V Genna, L Reyes-Fraile, J Iglesias-Fernandez… - Current Opinion in …, 2024 - Elsevier
RNA vaccines have made evident to society what was already known by the scientific
community: nucleic acids will be the “drugs of the future.” By modifying the genome …
community: nucleic acids will be the “drugs of the future.” By modifying the genome …
Advances in Antisense Oligo Technology for Sustainable Crop Protection
Since its inception, antisense oligonucleotides (ASOs) have been extensively used in
functional genomics. Recent advancements in chemical modification and delivery …
functional genomics. Recent advancements in chemical modification and delivery …
Structural dynamics of therapeutic nucleic acids with phosphorothioate backbone modifications
A Carlesso, J Hörberg, G Deganutti… - NAR Genomics and …, 2024 - academic.oup.com
Antisense oligonucleotides (ASOs) offer ground-breaking possibilities for selective
pharmacological intervention for any gene product-related disease. Therapeutic ASOs …
pharmacological intervention for any gene product-related disease. Therapeutic ASOs …
Comparison of interaction between antimiR and microRNA versus HDO-antimiR and microRNA by molecular dynamics simulation
K Nishina, K Yoshioka, T Yokota… - … , Nucleotides & Nucleic …, 2024 - Taylor & Francis
Recently, we found DNA/RNA heteroduplex oligonucleotide-based antimiR (HDO-antimiR)
can more efficiently inhibit the target miRNA than conventional antimiR after its cellular …
can more efficiently inhibit the target miRNA than conventional antimiR after its cellular …
Separation of isobaric phosphorothioate oligonucleotides in capillary electrophoresis: study of the influence of cationic cyclodextrins on chemo and stereoselectivity
MK Ghassemi, V Hurlet, J Crommen… - Frontiers in Analytical …, 2024 - frontiersin.org
Phosphorothioate (PS) oligonucleotides have drawn more and more attention lately due to
their great therapeutic potential. The presence of one (or several) phosphorothioate moiety …
their great therapeutic potential. The presence of one (or several) phosphorothioate moiety …
[PDF][PDF] Studies on Structure and Dynamics of Bridged Nucleic Acid based ASOs Using Density Functional Theory and Molecular Dynamics Approach for Targeted RNA …
D Dowerah - 2024 - agnee.tezu.ernet.in
Studies on Structure and Dynamics of Bridged Nucleic Acid based ASOs Using Density
Functional Theory and Molecular Dynamics App Page 1 Studies on Structure and Dynamics of …
Functional Theory and Molecular Dynamics App Page 1 Studies on Structure and Dynamics of …
[PDF][PDF] of the thesis Investigations of Noncanonical Nucleic Acids
Z Zhang - J. Phys. Chem. B, 2021 - is.muni.cz
Noncanonical nucleic acid structures, which play crucial roles in a variety of biological
processes, deserve in-depth investigations. Molecular Dynamics (MD) simulations have …
processes, deserve in-depth investigations. Molecular Dynamics (MD) simulations have …