Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a
role of mitochondrial metabolism in muscle function and in the development of many …

Programmed cell death protein 1 or Programmed death-1 (PD-1) and Programmed Cell
Death Ligand 1 (PD-L1) research have tremendously been taken into great consideration in …

Image-based cell/colony analyses offer promising solutions to compensate for the lack of
quality control (QC) tools for noninvasive monitoring of cultured cells, a regulatory challenge …

Many fields of study, including medical imaging, granular physics, colloidal physics, and
active matter, require the precise identification and tracking of particle-like objects in images …

Collective cell migration is observed during morphogenesis, angiogenesis, and wound
healing, and this type of cell migration also contributes to efficient metastasis in some kinds …

In fluorescence microscopy imaging, the segmentation of adjacent cell membranes within
cell aggregates, multicellular samples, tissue, organs, or whole organisms remains a …

The wound healing assay is widely used for the quantitative analysis of highly regulated
cellular events. In this essay, a wound is voluntarily produced on a confluent cell monolayer …

The key protein in the canonical Wnt pathway is β-catenin, which is phosphorylated both in
absence and presence of Wnt signals by different kinases. Upon activation in the cytoplasm …

2 Background: Active Contour Models and Multiple-Object Segmentation 11 2.1 Membrane
Detection in Fluorescence Microscopy............... 12 2.1. 1 Fluorescence …

Elongated structures are widely found in biological systems such as cell cytoskeleton and
neurons dendritic tree. These structures are observed through optical microscopy and …