Brain-derived neurotrophic factor (BDNF) is one of the most distributed and extensively
studied neurotrophins in the mammalian brain. BDNF signals through the tropomycin …

Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal
survival and growth. The signaling cascades initiated by BDNF and its receptor are the key …

Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Depression is the most prevalent and among the most debilitating of psychiatric disorders.
The precise neurobiology of this illness is unknown. Several lines of evidence suggest that …

Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of
depressed patients and at least the reduction in serum levels is reversible upon successful …

Depression is a well-known disabling mental illness characterized by sadness, loss of
interest in activities, and decreased energy. The symptoms of depression are usually …

Chronic exposure to uncontrollable stress causes loss of spines and dendrites in the
prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of …

Older individuals often experience declines in cognitive function after events (eg infection, or
injury) that trigger activation of the immune system. This occurs at least in part because …

Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions,
via activation of its high affinity receptor, tropomysin related kinase B (TrkB). In addition …

Neurotrophic factors play a key role in development, differentiation, synaptogenesis, and
survival of neurons in the brain as well as in the process of their adaptation to external …