Betulin and its derivatives as novel compounds with different pharmacological effects
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …
which possess a wide range of pharmacological activities. Recent evidence indicates that B …
Neuroprotective properties of Betulin, Betulinic acid, and Ursolic acid as triterpenoids derivatives: A comprehensive review of mechanistic studies
Cognitive deficits are the main outcome of neurological disorders whose occurrence has
risen over the past three decades. Although there are some pharmacologic approaches …
risen over the past three decades. Although there are some pharmacologic approaches …
Betulin inhibits lung metastasis by inducing cell cycle arrest, autophagy, and apoptosis of metastatic colorectal cancer cells
Background: Colorectal cancer (CRC) is one of the diseases with high prevalence and
mortality worldwide. In particular, metastatic CRC shows low probability of surgery and lacks …
mortality worldwide. In particular, metastatic CRC shows low probability of surgery and lacks …
Using a Caenorhabditis elegans Parkinson's Disease Model to Assess Disease Progression and Therapy Efficiency
S Hughes, M van Dop, N Kolsters, D van de Klashorst… - Pharmaceuticals, 2022 - mdpi.com
Despite Parkinson's Disease (PD) being the second most common neurodegenerative
disease, treatment options are limited. Consequently, there is an urgent need to identify and …
disease, treatment options are limited. Consequently, there is an urgent need to identify and …
[HTML][HTML] Tissue regeneration effect of betulin via inhibition of ROS/MAPKs/NF-ĸB axis using zebrafish model
T Ouyang, H Yin, J Yang, Y Liu, S Ma - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Betulin is the primary anti-inflammatory component of Betula platyphylla suk. cortex (birch
bark), a time-honored Traditional Chinese Medicine (TCM) for healing trauma and tissue …
bark), a time-honored Traditional Chinese Medicine (TCM) for healing trauma and tissue …
Betulinic acid, a natural PDE inhibitor restores hippocampal cAMP/cGMP and BDNF, improve cerebral blood flow and recover memory deficits in permanent BCCAO …
Vascular dementia (VaD) is the second most common form of senile dementia, embraces
memory deficits, neuroinflammation, executive function damage, mood and behavioral …
memory deficits, neuroinflammation, executive function damage, mood and behavioral …
Using Caenorhabditis elegans to Model Therapeutic Interventions of Neurodegenerative Diseases Targeting Microbe-Host Interactions
Emerging evidence from both clinical studies and animal models indicates the importance of
the interaction between the gut microbiome and the brain in the pathogenesis of …
the interaction between the gut microbiome and the brain in the pathogenesis of …
Neuroprotective Effects of Betulin in Pharmacological and Transgenic Caenorhabditis elegans Models of Parkinson's Disease
Parkinson's disease (PD) is the second most common degenerative disorder of the central
nervous system in the elderly. It is characterized by progressive loss of dopaminergic …
nervous system in the elderly. It is characterized by progressive loss of dopaminergic …
Betula utilis extract prolongs life expectancy, protects against amyloid-β toxicity and reduces Alpha Synuclien in Caenorhabditis elegans via DAF-16 and SKN-1
Betula utilis (BU), an important medicinal plant that grows in high altitudes of the Himalayan
region, has been utilized traditionally due to it's antibacterial, hepatoprotective, and anti …
region, has been utilized traditionally due to it's antibacterial, hepatoprotective, and anti …
Protective effect of betulinic acid against intracerebroventricular streptozotocin induced cognitive impairment and neuronal damage in rats: possible neurotransmitters …
M Kaundal, R Deshmukh, M Akhtar - Pharmacological Reports, 2018 - Elsevier
Background The purpose of the study was to explore the therapeutic potential of Betulinic
acid (BA) in streptozotocin (STZ) induced memory damage in experimental rats. Methods …
acid (BA) in streptozotocin (STZ) induced memory damage in experimental rats. Methods …