Abstract The RNA polymerase II (Pol II) pre-initiation complex (PIC) is a critical node in
eukaryotic transcription regulation, and its formation is the major rate-limiting step in …

Abstract Knowledge of the three-dimensional structures of proteins and other biological
macromolecules often aids understanding of how they perform complicated tasks in the cell …

INTRODUCTION RNA polymerase II (Pol II)–mediated transcription initiation requires
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …

Epigenetic regulation enables tumors to respond to changing environments during tumor
progression and metastases and facilitates treatment resistance. Targeting chromatin …

Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …

Whereas the core nucleosome is thought to serve as a packaging device for the coiling and
contraction in length of genomic DNA, we suggest that it serves primarily in the regulation of …

The landmark 1969 discovery of nuclear RNA polymerases I, II and III in diverse eukaryotes
represented a major turning point in the field that, with subsequent elucidation of the distinct …

For the initiation of transcription, RNA polymerase II (Pol II) assembles with general
transcription factors on promoter DNA to form the pre-initiation complex (PIC). Here we …

In eukaryotic transcription initiation, a large multi-subunit pre-initiation complex (PIC) that
assembles at the core promoter is required for the opening of the duplex DNA and …

Gene transcription by RNA polymerase II (Pol II) is the first step in the expression of the
eukaryotic genome and a focal point for cellular regulation during development …