Elevated blood pressure and hyperglycaemia frequently coexist and are both components of
metabolic syndrome. Enhanced cardiovascular risk is strongly associated with diabetes and …

Drug repurposing has gained significant interest in recent years due to the high costs
associated with de novo drug development; however, comprehensive pharmacological …

Currently, about 40% of approved drugs and nearly 90% of drug candidates are poorly
water-soluble drugs. Low solubility reduces the likelihood that these drugs can be effectively …

Tegafur (TGF) is a broad-spectrum anti-tumor drug, but it suffers from fast metabolism and
consequently poor oral absorption. Myricetin (MYR) is a flavonoid with anti-tumor activity …

Introduction Hypertension is a significant risk factor in heart failure for worldwide patients.
More than half of hypertensive patients suffer from heart failure. Recently, sacubitril/valsartan …

Objectives: Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative
disorder. The proportion of elderly individuals at risk for AD and cardiovascular problems …

Objectives: Identify the mechanism of action of sacubitril/valsartan. Summarize the
indications for initiating sacubitril/valsartan therapy. Review the adverse event profile of …

The progress and growth of drug discovery and development (DDD) in the past five decades
are reviewed in terms of the changing trends over the years. The importance of the …

Cocrystallization of the drug–drug salt-cocrystal of the histone deacetylase inhibitor (HDACi)
panobinostat (PAN) and b-rapidly accelerated fibrosarcoma (BRAF) inhibitor dabrafenib …

Interventions: We chose general liver protection methods to improve her hepatic function,
including magnesium isoglycyrrhizinate at 100 mg daily and polyene phosphatidylcholine …