The amyloid-β pathway in Alzheimer's disease

H Hampel, J Hardy, K Blennow, C Chen, G Perry… - Molecular …, 2021 - nature.com
Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …

Bee venom: Overview of main compounds and bioactivities for therapeutic interests

R Wehbe, J Frangieh, M Rima, D El Obeid, JM Sabatier… - Molecules, 2019 - mdpi.com
Apitherapy is an alternate therapy that relies on the usage of honeybee products, most
importantly bee venom for the treatment of many human diseases. The venom can be …

[HTML][HTML] Is Alzheimer's disease a type 3 diabetes? A critical appraisal

R Kandimalla, V Thirumala, PH Reddy - Biochimica et Biophysica Acta …, 2017 - Elsevier
Recently researchers proposed the term 'Type-3-Diabetes' for Alzheimer's disease (ad)
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2 …

Impact of HMGB1, RAGE, and TLR4 in Alzheimer's disease (AD): from risk factors to therapeutic targeting

YN Paudel, E Angelopoulou, C Piperi, I Othman… - Cells, 2020 - mdpi.com
Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a leading cause
of dementia, with accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) as …

Astrocyte senescence: evidence and significance

J Cohen, C Torres - Aging cell, 2019 - Wiley Online Library
Astrocytes participate in numerous aspects of central nervous system (CNS) physiology
ranging from ion balance to metabolism, and disruption of their physiological roles can …

Alzheimer's disease and type 2 diabetes: a critical assessment of the shared pathological traits

S Chatterjee, A Mudher - Frontiers in neuroscience, 2018 - frontiersin.org
Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most
prevalent diseases in the elderly population worldwide. A growing body of epidemiological …

Transcriptomic profiling of microglia and astrocytes throughout aging

J Pan, N Ma, B Yu, W Zhang, J Wan - Journal of Neuroinflammation, 2020 - Springer
Background Activation of microglia and astrocytes, a prominent hallmark of both aging and
Alzheimer's disease (AD), has been suggested to contribute to aging and AD progression …

Phospholipids of animal and marine origin: Structure, function, and anti-inflammatory properties

R Lordan, A Tsoupras, I Zabetakis - Molecules, 2017 - mdpi.com
In this review paper, the latest literature on the functional properties of phospholipids in
relation to inflammation and inflammation-related disorders has been critically appraised …

Neuroinflammation as a factor of neurodegenerative disease: thalidomide analogs as treatments

YJ Jung, D Tweedie, MT Scerba… - Frontiers in Cell and …, 2019 - frontiersin.org
Neuroinflammation is initiated when glial cells, mainly microglia, are activated by threats to
the neural environment, such as pathogen infiltration or neuronal injury. Although …

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers

Y Deming, Z Li, M Kapoor, O Harari, JL Del-Aguila… - Acta …, 2017 - Springer
More than 20 genetic loci have been associated with risk for Alzheimer's disease (AD), but
reported genome-wide significant loci do not account for all the estimated heritability and …