Obstructive sleep apnea, cognition and Alzheimer's disease: a systematic review integrating three decades of multidisciplinary research

OM Bubu, AG Andrade, OQ Umasabor-Bubu… - Sleep medicine …, 2020 - Elsevier
Increasing evidence links cognitive-decline and Alzheimer's disease (AD) to various sleep
disorders, including obstructive sleep apnea (OSA). With increasing age, there are …

Sleep, cognitive impairment, and Alzheimer's disease: a systematic review and meta-analysis

OM Bubu, M Brannick, J Mortimer, O Umasabor-Bubu… - Sleep, 2017 - academic.oup.com
Abstract Study Objectives: Mounting evidence implicates disturbed sleep or lack of sleep as
one of the risk factors for Alzheimer's disease (AD), but the extent of the risk is uncertain. We …

The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

X Liu, Y Ma, R Ouyang, Z Zeng, Z Zhan, H Lu… - Journal of …, 2020 - Springer
Obstructive sleep apnea syndrome (OSAS), a state of sleep disorder, is characterized by
repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Previous studies …

Sleep-disordered breathing and the risk of Alzheimer's disease

C Liguori, M Maestri, M Spanetta, F Placidi… - Sleep Medicine …, 2021 - Elsevier
Sleep-disordered breathing is highly prevalent in the elderly population. Obstructive sleep
apnea (OSA) represents the most common sleep disorder among the adult and elderly …

[HTML][HTML] Obstructive sleep apnea and its treatment in aging: effects on Alzheimer's disease biomarkers, cognition, brain structure and neurophysiology

AE Mullins, K Kam, A Parekh, OM Bubu, RS Osorio… - Neurobiology of …, 2020 - Elsevier
Here we review the impact of obstructive sleep apnea (OSA) on biomarkers of Alzheimer's
disease (AD) pathogenesis, neuroanatomy, cognition and neurophysiology, and present the …

Chronic intermittent hypoxia induces oxidative stress and inflammation in brain regions associated with early‐stage neurodegeneration

B Snyder, B Shell, JT Cunningham… - Physiological …, 2017 - Wiley Online Library
Sleep apnea is a common comorbidity of neurodegenerative diseases, such as Alzheimer's
disease (AD) and Parkinson's disease (PD). Previous studies have shown an association …

Reviewing the relationship between OSA and cognition: W here do we go from here?

RS Bucks, M Olaithe, I Rosenzweig, MJ Morrell - Respirology, 2017 - Wiley Online Library
Obstructive sleep apnoea (OSA) is a disorder of breathing during sleep resulting in
temporary reduction in cerebral oxygenation and sleep disruption. A growing body of …

[HTML][HTML] Vigilance: discussion of related concepts and proposal for a definition

MKM van Schie, GJ Lammers, R Fronczek… - Sleep Medicine, 2021 - Elsevier
We reviewed current definitions of vigilance to propose a definition, applicable in sleep
medicine. As previous definitions contained terms such as attention, alertness, and arousal …

The cognitive effects of obstructive sleep apnea: an updated meta-analysis

EK Stranks, SF Crowe - Archives of clinical neuropsychology, 2016 - academic.oup.com
This meta-analysis set out to ascertain the cognitive function of obstructive sleep apnea
(OSA) patients as measured through objective neuropsychological tests. The meta-analysis …

Comorbid depression in obstructive sleep apnea: an under-recognized association

AS BaHammam, T Kendzerska, R Gupta… - Sleep and …, 2016 - Springer
Background Obstructive sleep apnea (OSA) and depression may coexist in the same
patient. This article aims to review the link between OSA and comorbid depression and …