SARS-CoV-2 vaccines based on the spike glycoprotein and implications of new viral variants

D Martínez-Flores, J Zepeda-Cervantes… - Frontiers in …, 2021 - frontiersin.org
Coronavirus 19 Disease (COVID-19) originating in the province of Wuhan, China in 2019, is
caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), whose …

Recombinant protein vaccines, a proven approach against coronavirus pandemics

J Pollet, WH Chen, U Strych - Advanced drug delivery reviews, 2021 - Elsevier
With the COVID-19 pandemic now ongoing for close to a year, people all over the world are
still waiting for a vaccine to become available. The initial focus of accelerated global …

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial

KJ Chappell, FL Mordant, Z Li… - The Lancet Infectious …, 2021 - thelancet.com
Background Given the scale of the ongoing COVID-19 pandemic, the development of
vaccines based on different platforms is essential, particularly in light of emerging viral …

The COVID-19 vaccines: recent development, challenges and prospects

Y Yan, Y Pang, Z Lyu, R Wang, X Wu, C You, H Zhao… - Vaccines, 2021 - mdpi.com
The highly infectious coronavirus disease 2019 (COVID-19) associated with the pathogenic
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to become a …

Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant

B Akache, TM Renner, A Tran, L Deschatelets… - Scientific reports, 2021 - nature.com
The huge worldwide demand for vaccines targeting SARS-CoV-2 has necessitated the
continued development of novel improved formulations capable of reducing the burden of …

The current status of drug repositioning and vaccine developments for the COVID-19 pandemic

JH Won, H Lee - International Journal of Molecular Sciences, 2020 - mdpi.com
Since the outbreak of coronavirus disease 2019 (COVID-19) was first identified, the world
has vehemently worked to develop treatments and vaccines against severe acute …

Structure and antigenicity of divergent Henipavirus fusion glycoproteins

A Isaacs, YS Low, KL Macauslane, J Seitanidou… - Nature …, 2023 - nature.com
In August 2022, a novel henipavirus (HNV) named Langya virus (LayV) was isolated from
patients with severe pneumonic disease in China. This virus is closely related to Mòjiāng …

Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine

CLD McMillan, JJY Choo, A Idris, A Supramaniam… - Science …, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than
160 million people and resulted in more than 3.3 million deaths, and despite the availability …

An adjuvanted subunit SARS-CoV-2 spike protein vaccine provides protection against Covid-19 infection and transmission

K Tabynov, N Turebekov, M Babayeva, G Fomin… - npj Vaccines, 2022 - nature.com
Recombinant protein approaches offer major promise for safe and effective vaccine
prevention of SARS-CoV-2 infection. We developed a recombinant spike protein vaccine …