SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …
SARS-CoV-2 subunit vaccine adjuvants and their signaling pathways
Introduction Vaccines are the agreed upon weapon against the COVID-19 pandemic. This
review discusses about COVID-19 subunit vaccines adjuvants and their signaling pathways …
review discusses about COVID-19 subunit vaccines adjuvants and their signaling pathways …
COVID-19 vaccine platforms: Challenges and safety contemplations
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a
pandemic as of March 2020, creating a global crisis and claiming millions of lives. To halt …
pandemic as of March 2020, creating a global crisis and claiming millions of lives. To halt …
Safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2: a randomised, double-blind, placebo-controlled, phase 1 trial
KJ Chappell, FL Mordant, Z Li… - The Lancet Infectious …, 2021 - thelancet.com
Background Given the scale of the ongoing COVID-19 pandemic, the development of
vaccines based on different platforms is essential, particularly in light of emerging viral …
vaccines based on different platforms is essential, particularly in light of emerging viral …
Immunogenic and efficacious SARS-CoV-2 vaccine based on resistin-trimerized spike antigen SmT1 and SLA archaeosome adjuvant
The huge worldwide demand for vaccines targeting SARS-CoV-2 has necessitated the
continued development of novel improved formulations capable of reducing the burden of …
continued development of novel improved formulations capable of reducing the burden of …
Structure and antigenicity of divergent Henipavirus fusion glycoproteins
A Isaacs, YS Low, KL Macauslane, J Seitanidou… - Nature …, 2023 - nature.com
In August 2022, a novel henipavirus (HNV) named Langya virus (LayV) was isolated from
patients with severe pneumonic disease in China. This virus is closely related to Mòjiāng …
patients with severe pneumonic disease in China. This virus is closely related to Mòjiāng …
Complete protection by a single-dose skin patch–delivered SARS-CoV-2 spike vaccine
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than
160 million people and resulted in more than 3.3 million deaths, and despite the availability …
160 million people and resulted in more than 3.3 million deaths, and despite the availability …
An adjuvanted subunit SARS-CoV-2 spike protein vaccine provides protection against Covid-19 infection and transmission
K Tabynov, N Turebekov, M Babayeva, G Fomin… - npj Vaccines, 2022 - nature.com
Recombinant protein approaches offer major promise for safe and effective vaccine
prevention of SARS-CoV-2 infection. We developed a recombinant spike protein vaccine …
prevention of SARS-CoV-2 infection. We developed a recombinant spike protein vaccine …
Therapeutic protein-based vaccines
Infectious diseases are reported worldwide, and the emergence of highly mutated antibiotic-
resistant strains is a major concern globally. Developing efficient vaccines is the only way to …
resistant strains is a major concern globally. Developing efficient vaccines is the only way to …
A platform technology for generating subunit vaccines against diverse viral pathogens
The COVID-19 pandemic response has shown how vaccine platform technologies can be
used to rapidly and effectively counteract a novel emerging infectious disease. The speed of …
used to rapidly and effectively counteract a novel emerging infectious disease. The speed of …