Computational modelling of the lungs is an active field of study that integrates computational
advances with lung biophysics, biomechanics, physiology and medical imaging to promote …

Bronchial thermoplasty is a relatively new but seemingly effective treatment in subjects with
asthma who do not respond to conventional therapy. Although the favored mechanism is …

Most measures of lung health independently characterise either global lung function or
regional lung structure. The ability to measure airflow and lung function regionally would …

The aim of this study was to assess the association between regional tidal volume (Vt),
regional functional residual capacity (FRC), and the expression of genes linked with …

We have developed an x-ray imaging system for in vivo four-dimensional computed
tomography (4DCT) of small animals for pre-clinical lung investigations. Our customized …

Asthma is a disease involving both airway remodelling (eg thickening of the airway wall) and
acute, reversible airway narrowing driven by airway smooth muscle contraction. Both of …

Bronchial thermoplasty is a recent treatment for asthma in which ablative thermal energy is
delivered to specific large airways according to clinical guidelines. Therefore, current …

Mice are a valuable model for elegant studies of complex, system-dependent diseases,
including pulmonary diseases. Current tools to assess lung function in mice are either …

Is asthma predominately a disease of the large or small airways? The question has vexed
these pages for at least 50 years (1–4) and although a consensus appears to be emerging …

The beating heart is known to produce pressure and airflow oscillations in the lungs of
mammals. This phenomenon is often disregarded as detailed measurement of its effects in …