Plasmodium spp. parasites are the causative agents of malaria in humans and animals, and
they are exceptionally diverse in their morphology and life cycles. They grow and develop in …

Gametocytes are the only form of the malaria parasite that is transmissible to the mosquito
vector. They are present at low levels in blood circulation and significant knowledge gaps …

Background Plasmodium vivax exacts a significant toll on health worldwide, yet few efforts to
date have quantified the extent and temporal trends of its global distribution. Given the …

The efficient spread of malaria from infected humans to mosquitoes is a major challenge for
malaria elimination initiatives. Gametocytes are the only Plasmodium life stage infectious to …

Plasmodium vivax is the most geographically widespread human malaria parasite. Global
malaria efforts have been less successful at reducing the burden of P. vivax compared to P …

Background A very large biomass of intact asexual-stage malaria parasites accumulates in
the spleen of asymptomatic human individuals infected with Plasmodium vivax. The …

BACKGROUND The biology of Plasmodium vivax is markedly different from that of P.
falciparum; how this shapes the immune response to infection remains unclear. To address …

Apicomplexan parasites, such as human malaria parasites, have complex lifecycles
encompassing multiple and diverse environmental niches. Invading, replicating, and …

More than one-third of the world's population is exposed to Plasmodium vivax malaria,
mainly in Asia. P. vivax preferentially invades reticulocytes (immature red blood cells) …

Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths
each year, concentrated in Africa and in young children, but much of the world's population …