Additive manufacturing of tissues and organs

FPW Melchels, MAN Domingos, TJ Klein… - Progress in polymer …, 2012 - Elsevier
Additive manufacturing techniques offer the potential to fabricate organized tissue constructs
to repair or replace damaged or diseased human tissues and organs. Using these …

Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds

SF Badylak, D Taylor, K Uygun - Annual review of biomedical …, 2011 - annualreviews.org
The definitive treatment for end-stage organ failure is orthotopic transplantation. However,
the demand for transplantation far exceeds the number of available donor organs. A …

Current and future perspectives on skin tissue engineering: key features of biomedical research, translational assessment, and clinical application

JR Yu, J Navarro, JC Coburn, B Mahadik… - Advanced …, 2019 - Wiley Online Library
The skin is responsible for several important physiological functions and has enormous
clinical significance in wound healing. Tissue engineered substitutes may be used in …

Readily available tissue-engineered vascular grafts

SLM Dahl, AP Kypson, JH Lawson, JL Blum… - Science translational …, 2011 - science.org
Autologous or synthetic vascular grafts are used routinely for providing access in
hemodialysis or for arterial bypass in patients with cardiovascular disease. However, some …

Chitosan/silk fibroin-based, Schwann cell-derived extracellular matrix-modified scaffolds for bridging rat sciatic nerve gaps

Y Gu, J Zhu, C Xue, Z Li, F Ding, Y Yang, X Gu - Biomaterials, 2014 - Elsevier
Extracellular matrix (ECM) plays a prominent role in establishing and maintaining an ideal
microenvironment for tissue regeneration, and ECM scaffolds are used as a feasible …

Enhancing cell therapies from the outside in: cell surface engineering using synthetic nanomaterials

MT Stephan, DJ Irvine - Nano today, 2011 - Elsevier
Therapeutic treatments based on the injection of living cells are in clinical use and
preclinical development for diseases ranging from cancer to cardiovascular disease to …

A review of biomimetic scaffolds for bone regeneration: toward a cell‐free strategy

S Jiang, M Wang, J He - Bioengineering & Translational …, 2021 - Wiley Online Library
In clinical terms, bone grafting currently involves the application of autogenous, allogeneic,
or xenogeneic bone grafts, as well as natural or artificially synthesized materials, such as …

Towards organ printing: engineering an intra-organ branched vascular tree

RP Visconti, V Kasyanov, C Gentile… - Expert opinion on …, 2010 - Taylor & Francis
Importance of the field: Effective vascularization of thick three-dimensional engineered
tissue constructs is a problem in tissue engineering. As in native organs, a tissue …

Implantation of completely biological engineered grafts following decellularization into the sheep femoral artery

ZH Syedain, LA Meier, MT Lahti… - … Engineering Part A, 2014 - liebertpub.com
The performance of completely biological, decellularized engineered allografts in a sheep
model was evaluated to establish clinical potential of these unique arterial allografts. The 4 …

Acellular biomaterials: an evolving alternative to cell-based therapies

JA Burdick, RL Mauck, JH Gorman III… - Science translational …, 2013 - science.org
Acellular biomaterials can stimulate the local environment to repair tissues without the
regulatory and scientific challenges of cell-based therapies. A greater understanding of the …