Microbial communities are shaped by positive and negative interactions ranging from
competition to mutualism. In the context of the mammalian gut and its microbial inhabitants …

It has been 10 years since the introduction of modern transposon-insertion sequencing (TIS)
methods, which combine genome-wide transposon mutagenesis with high-throughput …

Efforts to model the human gut microbiome in mice have led to important insights into the
mechanisms of host-microbe interactions. However, the model communities studied to date …

Conventional CRISPR–Cas systems maintain genomic integrity by leveraging guide RNAs
for the nuclease-dependent degradation of mobile genetic elements, including plasmids and …

Individuals vary widely in their responses to medicinal drugs, which can be dangerous and
expensive owing to treatment delays and adverse effects. Although increasing evidence …

The human body carries vast communities of microbes that provide many benefits. Our
microbiome is complex and challenging to understand, but evolutionary theory provides a …

Plant microbiome research highlights the importance of indigenous microbial communities
for host phenotypes such as growth and health. It aims to discover the molecular basis by …

INTRODUCTION The gut microbiota is implicated in the metabolism of many medical drugs,
with consequences for interpersonal variation in drug efficacy and toxicity. However …

Over the last decade, our appreciation for the contribution of resident gut microorganisms—
the gut microbiota—to human health has surged. However, progress is limited by the sheer …

Sphingolipids are structural membrane components and important eukaryotic signaling
molecules. Sphingolipids regulate inflammation and immunity and were recently identified …