Proteins are large, complex molecules responsible for various biological processes.
However, protein misfolding may lead to various life-threatening diseases. Therefore, it is …

Recent advances in optical and spectroscopic technologies have enabled a plethora of
Raman spectrometers that are suitable for studies of protein pharmaceuticals. Highly …

We present a method for predicting the regions of the sequences of peptides and proteins
that are most important in promoting their aggregation and amyloid formation. The method …

Objectives Currently, the exact reasons why different α‐synucleinopathies exhibit variable
pathologies and phenotypes are still unknown. A potential explanation may be the existence …

Protein misfolding and aggregation are associated with more than twenty diseases, such as
neurodegenerative diseases and metabolic diseases. The amyloid oligomers and fibrils may …

Excessive nuclear factor-κB (NF-κB) activation mediated by tumor necrosis factor α (TNFα)
plays a critical role in inflammation. Here we demonstrate that angiopoietin-like 8 …

Dark days for diabetic patients were transformed into an era of hope when the therapeutic
usage of insulin was discovered. However, those initial glory days changed to being …

El objetivo de la presente investigación fue analizar empíricamente la relación entre
innovación, emprendimiento y desarrollo local del pueblo de Salinas de Guaranda …

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Protein fibrils drive the onset and progression of many diseases in a prion-like manner, ie
they transcellular propagate through the extracellular space to health cells to initiate toxic …