The laboratory toxicologist is frequently faced with the challenge of selecting appropriate
vehicles or developing utilitarian formulations for use in in vivo nonclinical safety …

Formulation of nonclinical evaluations is a challenge, with the fundamental need to achieve
multiples of the clinical exposure complicated by differences in species and routes of …

Cisplatin [cis-diamminechloroplatinum (II)](CDDP) is a potent antineoplastic agent used for
the treatment of a wide range of cancers (Saad et al., 2004; Wang et al., 2004) …

Cisplatin (Cis) is an effective chemotherapeutic agent successfully used in the treatment of a
wide range of malignancies while its usage is limited due to its dose-dependent toxicity. The …

This study evaluates the protective effects of Thymoquinone (Tq) and Curcumin (Cur) in
models of cisplatin-induced renal toxicity. Proliferation studies were carried out in HEK-293 …

The present study was aimed to investigate the ability of quercetin (QE) to ameliorate
adverse effects of cisplatin (Cis.) on the renal tissue antioxidants by investigating the kidney …

This study aimed to assess the protective effect of hesperidin (HES) and rutin (RUT) against
cisplatin‐induced nephrotoxicity in male rats. Cisplatin (5 mg/kg, intraperitoneal) caused …

Cisplatin is chemotherapeutic drug used in treatment of malignancies. However, its clinical
utility is limited by nephrotoxicity. The purpose of present study is to investigate biochemical …

Cisplatin is broadly used in the treatment of malignancies. However, the high incidence of
nephrotoxicity following cisplatin use deters its clinical utility. Former studies have shown …

Problem statement: Nephrotoxicity is a major complication and a dose limiting factor for
cisplatin therapy. Cisplatin mediated nephrotoxicity is remarkably documented by reactive …