Platelets are anucleated cell elements produced by fragmentation of the cytoplasm of
megakaryocytes and have a unique metabolic phenotype compared with circulating …

New findings unravel novel mechanotransduction pathways and effector functions in
platelets, establishing mechanobiology as a pivotal component of platelet function. These …

Platelet activation plays a key role in cardiovascular diseases. The generation of
mitochondrial reactive oxygen species (ROS) has been described as a critical step required …

Dysfunction of the immune response is regarded as a prominent feature of neurological
diseases, including neurodegenerative diseases, malignant tumors, acute neurotraumatic …

Physiological processes such as blood clotting and wound healing as well as pathologies
such as fibroses and musculoskeletal contractures, all involve biological materials …

In addition to the classical biological and biochemical framework, blood clots can also be
considered as active biomaterials composed of dynamically contracting platelets, nascent …

Trauma induces a change in nearly every observable aspect of hemostasis, generally
tipping the balance toward trauma-induced coagulopathy (TIC) and bleeding in the critical …

Blood clot contraction plays an important role in wound healing and hemostasis. Although
clot contraction is known to be driven by platelets, how single platelet forces relate to the …

Hypochlorite (HOCl), a strong oxidant and antimicrobial agent, has been proposed to be
associated with hemostatic abnormalities during inflammatory response. However, its …

BACKGROUND In retrospective studies, it has been shown that differences in storage
variables of platelet (PLT) concentrates (PCs) are partially donor dependent. It was our aim …