Chromatin immunoprecipitation followed by sequencing (ChIP-seq) analysis can detect
protein/DNA-binding and histone-modification sites across an entire genome. Recent …

Most genomic variants associated with phenotypic traits or disease do not fall within gene
coding regions, but in regulatory regions, rendering their interpretation difficult. We collected …

Trimethylation of histone H3 at lysine 4 (H3K4me3) is a chromatin modification known to
mark the transcription start sites of active genes. Here, we show that H3K4me3 domains that …

Lymphatic vessels are lined by lymphatic endothelial cells (LECs), and are critical for health.
However, the role of metabolism in lymphatic development has not yet been elucidated …

Mammalian genomes are viewed as functional organizations that orchestrate spatial and
temporal gene regulation. CTCF, the most characterized insulator-binding protein, has been …

ChIP-seq is increasingly being used for genome-wide profiling of histone modification
marks. It is of particular importance to compare ChIP-seq data of two different conditions …

Although elongation of telomeres is thought to be the prime function of reactivated
telomerase in cancers, this activity alone does not account for all of the properties that …

Chromosome conformation capture approaches have shown that interphase chromatin is
partitioned into spatially segregated Mb-sized compartments and sub-Mb-sized topological …

Mapping the chromosomal locations of transcription factors, nucleosomes, histone
modifications, chromatin remodeling enzymes, chaperones, and polymerases is one of the …

Trimethylation of histone H3 lysine 4 (H3K4me3) at the promoters of actively transcribed
genes is a universal epigenetic mark and a key product of Trithorax group action. Here, we …