The biochemistry and physiology of l-arginine have to be reconsidered in the light of the
recent discovery that the amino acid is the only substrate of all isoforms of nitric oxide …

A large body of evidence has appeared over the last 6 years suggesting that nitric oxide
biosynthesis is a key factor in the pathophysiological response of the brain to hypoxia …

The state of sleep consists of different phases that proceed in successive, tightly regulated
order through the night forming a physiological program, which for each individual is …

Brain ischemia is one of the leading causes of disability and mortality worldwide. Nitric oxide
(NO•), a molecule that is involved in the regulation of proper blood flow, vasodilation …

Ischaemic stroke is the second or third leading cause of death in developed countries. In the
last two decades substantial research and efforts have been made to understand the …

Tumour hypoxia is the result of an imbalance in oxygen supply and demand. It is an adverse
prognostic indicator in cancer as it modulates tumour progression and treatment. Many …

Long‐term exposure to stress has detrimental effects on several brain functions in many
species, including humans, and leads to neurodegenerative changes. However, the …

Being the second most common cause of death in the industrial countries and one of the
major causes of death and disability, stroke has a great effect on public health and is the …

Maslinic acid is a pentacyclic triterpene found in a variety of natural sources, ranging from
herbal remedies used in traditional Asian medicine to edible vegetables and fruits present in …

Enzymatically derived nitric oxide (NO) has been implicated in numerous physiological and
pathological processes in the brain. Whereas during development NO participates in …