Background. The concept of ischaemic preconditioning was introduced in the late 1980s.
The concept emerged that a brief subcritical ischaemic challenge could mobilize intrinsic …

Mitochondria are critical modulators of cell function and are increasingly recognized as
proximal sensors and effectors that ultimately determine the balance between cell survival …

Objective: Anesthetic preconditioning appears to be a viable strategy to treat ischemic
cerebral injury. Here we investigated 1) whether the protection conferred by sevoflurane …

Polyphenol (-)-epigallocatechin gallate (EGCG), the most abundant catechin of green tea,
appears to attenuate myocardial ischemia/reperfusion injury. We investigated the …

Glycosaminoglycan hyaluronan (HA), a major constituent of the endothelial glycocalyx,
helps to maintain vascular integrity. Preconditioning the heart with volatile anesthetic agents …

In recent years, there has been increased interest in the mechanisms involved in
anaesthetic-induced cardioprotection. It is not thoroughly understood how volatile …

IMPLICATIONS: A delayed window of volatile anesthetic preconditioning limits intracellular
Na+ and Ca+ 2, prevents the depletion of adenosine triphosphate, and improves function …

Methods Hearts from 2-month-old male Fisher 344 rats were exposed to 25 min global
ischaemia followed by 60 min reperfusion. Rats were divided into four groups prior to I/R …

Anesthetic preconditioning (APC), defined as brief exposure to inhalational anesthetics
before cardiac ischemia-reperfusion (I/R), limits injury in both animal models and in humans …

Current cellular models of ischemic preconditioning (IPC) rely on inducing preconditioning
in vitro and may not accurately represent complex pathways triggered by IPC in the intact …