Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has
resulted in the emergence of epitranscriptomics as a research field. The most abundant …

The field of RNA modification, also referred to as “epitranscriptomics,” is gaining more and
more interest from the scientific community. More than 160 chemical modifications have …

PCIF1 can mediate the methylation of N 6, 2′-O-dimethyladenosine (m6Am) in mRNA. Yet,
the detailed interplay between PCIF1 and the potential cofactors and its pathological …

Epitranscriptomic modifications have recently emerged into the spotlight of researchers due
to their vast regulatory effects on gene expression and thereby cellular physiology and …

Gastric cancer is the fourth most frequent cancer and has a high death rate. Immunotherapy
represented by PD-1 has brought hope for the treatment of advanced gastric cancer …

The fat mass and obesity-associated (FTO) gene was the first obesity-susceptibility gene
identified through a genome-wide association study (GWAS). A growing number of studies …

Epigenetic modifications have long been recognized as an essential level in transcriptional
regulation linking behavior and environmental conditions or stimuli with biological …

N 6, 2′-O-dimethyladenosine (m6Am) is a widespread RNA modification catalyzed by the
methyltransferase PCIF1 (phosphorylated CTD interacting factor 1). Despite its prevalence …

Abstract Background N6, 2'-O-dimethyladenosine (m6Am) is an abundant RNA methylation
modification on vertebrate mRNAs and is present in the transcription initiation region of …

Abstract N6-methyladenosine (m6A), is the most abundant post-transcriptional modification
of mRNA in biology. When the first nucleotide after the m7G cap is adenosine, it is …